P-Anisidine

p-Anisidine
Names
	Preferred IUPAC name 4-Methoxyaniline
	Other names para-Anisidine; 4-Aminoanisole; p-Aminoanisole
Identifiers
CAS Number	104-94-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:82388;
ChEMBL	ChEMBL295652 ;
ChemSpider	13869414 ;
ECHA InfoCard	100.002.959
EC Number	203-254-2;
KEGG	C19326 ;
PubChem CID	7732;
RTECS number	BZ5450000;
UNII	575917SNR4 ;
UN number	2431
CompTox Dashboard (EPA)	DTXSID7024532 ;
	InChI InChI=1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3 Key: BHAAPTBBJKJZER-UHFFFAOYSA-N ; InChI=1/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3;
	SMILES COc1ccc(cc1)N;
Properties
Chemical formula	C7H9NO
Molar mass	123.155 g·mol−1
Appearance	Light reddish brown solid
Odor	Fishy
Density	1.071 (at 57 °C)
Melting point	56 to 59 °C (133 to 138 °F; 329 to 332 K)
Boiling point	243 °C (469 °F; 516 K)
Solubility in water	Sparingly soluble
Solubility in other solvents	Soluble in ethanol, diethyl ether, acetone, benzene
Vapor pressure	0.006 mmHg (25 °C)
Magnetic susceptibility (χ)	-80.56·10−6 cm3/mol
Refractive index (nD)	1.5559
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Carcinogen
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H300, H310, H330, H350, H373, H400
Precautionary statements	P201, P202, P260, P262, P264, P270, P271, P273, P280, P281, P284, P301+P310, P302+P350, P304+P340, P308+P313, P310, P314, P320, P321, P322, P330, P361, P363, P391, P403+P233, P405, P501
Flash point	122 °C (252 °F; 395 K)
Autoignition; temperature	515 °C (959 °F; 788 K)
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	145 mg/kg (rabbit, oral); 130 mg/kg (mouse, oral); 140 mg/kg (rat, oral)
LDLo (lowest published)	100 mg/kg (mouse, oral)
	NIOSH (US health exposure limits):
PEL (Permissible)	TWA 0.5 mg/m3 [skin]
REL (Recommended)	TWA 0.5 mg/m3 [skin]
IDLH (Immediate danger)	50 mg/m3
Related compounds
Related compounds	o-Anisidine; m-Anisidine
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

p-Anisidine (or para-anisidine) is an organic compound with the formula CH₃OC₆H₄NH₂. A white solid, commercial samples can appear grey-brown owing to air oxidation. It is one of three isomers of anisidine, methoxy-containing anilines. It is prepared by reduction of 4-nitroanisole.^[8]

^ Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 669. doi:10.1039/9781849733069-00648. ISBN 978-0-85404-182-4. The names 'toluidine', 'anisidine', and 'phenetidine' for which o-, m-, and p- have been used to distinguish isomers, and 'xylidine' for which numerical locants, such as 2,3-, have been used, are no longer recommended, nor are the corresponding prefixes 'toluidine', 'anisidino', 'phenetidine', and 'xylidino'.
^ ^a ^b ^c Cite error: The named reference cdc was invoked but never defined (see the help page).
^ ^a ^b ^c ^d NIOSH Pocket Guide to Chemical Hazards. "#0035". National Institute for Occupational Safety and Health (NIOSH).
^ Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-98. ISBN 0-8493-0462-8.
^ "p-Anisidine safety and hazards". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-12-02.
^ p-Anisidine toxicity
^ ^a ^b "p-Anisidine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
^ Mitchell, Stephen C.; Waring, Rosemary H. (2000). "Aminophenols". Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH. doi:10.1002/14356007.a02_099. ISBN 3527306730.

[iupac2013-1] Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 669. doi:10.1039/9781849733069-00648. ISBN 978-0-85404-182-4. The names 'toluidine', 'anisidine', and 'phenetidine' for which o-, m-, and p- have been used to distinguish isomers, and 'xylidine' for which numerical locants, such as 2,3-, have been used, are no longer recommended, nor are the corresponding prefixes 'toluidine', 'anisidino', 'phenetidine', and 'xylidino'.

[cdc-2] Cite error: The named reference cdc was invoked but never defined (see the help page).

[NIOSH-3] NIOSH Pocket Guide to Chemical Hazards. "#0035". National Institute for Occupational Safety and Health (NIOSH).

[4] Weast, Robert C., ed. (1981). CRC Handbook of Chemistry and Physics (62nd ed.). Boca Raton, FL: CRC Press. p. C-98. ISBN 0-8493-0462-8.

[5] "p-Anisidine safety and hazards". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-12-02.

[6] -Anisidine toxicity

[IDLH-7] "p-Anisidine". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).

[Ullmann-8] Mitchell, Stephen C.; Waring, Rosemary H. (2000). "Aminophenols". Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH. doi:10.1002/14356007.a02_099. ISBN 3527306730.

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