P-Hydroxynorephedrine

p-Hydroxynorephedrine
Clinical data
Other names4-Hydroxynorephedrine
para-Hydroxynorephedrine
Identifiers
  • 4-(2-amino-1-hydroxypropyl)phenol
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC9H13NO2
Molar mass167.208 g·mol−1
3D model (JSmol)
  • [C@@H]([C@H](C)N)(O)C1=CC=C(O)C=C1
  • InChI=1S/C9H13NO2/c1-6(10)9(12)7-2-4-8(11)5-3-7/h2-6,9,11-12H,10H2,1H3/t6-,9-/m0/s1
  • Key:JAYBQRKXEFDRER-RCOVLWMOSA-N

p-Hydroxynorephedrine (PHN or 4-hydroxynorephedrine) is the para-hydroxy analog of norephedrine and an active sympathomimetic metabolite of amphetamine in humans.[1][2] When it occurs as a metabolite of amphetamine, it is produced from both p-hydroxyamphetamine and norephedrine.[2][3][4]

  1. ^ "p-Hydroxynorephedrine". NCBI. PubChem Compound. Retrieved 25 October 2013.
  2. ^ a b "Adderall XR Prescribing Information" (PDF). Medication Guide. United States Food and Drug Administration. Retrieved 7 October 2013.
  3. ^ "Amphetamine: Biomedical Effects and Toxicity". NCBI. Pubchem Compound. Retrieved 12 October 2013.
  4. ^ Santagati NA, Ferrara G, Marrazzo A, Ronsisvalle G (September 2002). "Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection". J. Pharm. Biomed. Anal. 30 (2): 247–55. doi:10.1016/S0731-7085(02)00330-8. PMID 12191709.