P21

CDKN1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
External IDsOMIM: 116899; MGI: 104556; HomoloGene: 333; GeneCards: CDKN1A; OMA:CDKN1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_078467
NM_000389
NM_001220777
NM_001220778
NM_001291549

NM_001111099
NM_007669

RefSeq (protein)

NP_001104569
NP_031695

Location (UCSC)Chr 6: 36.68 – 36.69 MbChr 17: 29.31 – 29.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes,[5] though is primarily associated with inhibition of CDK2.[6][7] p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.[8][9][10] This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.[11]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124762Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023067Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993). "p21 is a universal inhibitor of cyclin kinases". Nature. 366 (6456): 701–4. Bibcode:1993Natur.366..701X. doi:10.1038/366701a0. PMID 8259214. S2CID 4362507.
  6. ^ Abbas, Tarek; Dutta, Anindya (2009). "p21 in cancer: intricate networks and multiple activities". Nature Reviews Cancer. 9 (6): 400–414. doi:10.1038/nrc2657. PMC 2722839. PMID 19440234.
  7. ^ Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751.
  8. ^ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (November 1993). "WAF1, a potential mediator of p53 tumor suppression". Cell. 75 (4): 817–25. doi:10.1016/0092-8674(93)90500-P. PMID 8242752.
  9. ^ Bunz F, et al. (1998). "Requirement for p53 and p21 to sustain G2 arrest after DNA damage". Science. 282 (5393): 1497–1501. doi:10.1126/science.282.5393.1497. PMID 9822382.
  10. ^ Waldman, Todd, Kenneth W. Kinzler, and Bert Vogelstein. "p21 is necessary for the p53-mediated G1 arrest in human cancer cells." Cancer research 55.22 (1995): 5187-5190.
  11. ^ "Entrez Gene: CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)".