P2RY1

P2RY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XNV, 4XNW
Identifiers
Aliases	P2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDs	OMIM: 601167; MGI: 105049; HomoloGene: 1926; GeneCards: P2RY1; OMA:P2RY1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	152,841,439 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	60,916,403 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; endothelial cell; ; oral cavity; ; internal globus pallidus; ; visceral pleura; ; amniotic fluid; ; placenta; ; nucleus accumbens; ; tibia; ; lower lobe of lung;
	Top expressed in
	lumbar spinal ganglion; ; duodenum; ; islet of Langerhans; ; granulocyte; ; jejunum; ; esophagus; ; lip; ; muscle of thigh; ; embryo; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	A1 adenosine receptor binding; G protein-coupled receptor activity; scaffold protein binding; ADP binding; G protein-coupled purinergic nucleotide receptor activity; signal transducer activity; protein binding; protein heterodimerization activity; G protein-coupled ATP receptor activity; ATP binding; nucleotide binding; signaling receptor activity;
Cellular component	cell body; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; integral component of plasma membrane; cell surface; dendrite; basolateral plasma membrane; apical plasma membrane; mitochondrion; postsynaptic density; glutamatergic synapse; integral component of presynaptic active zone membrane; cilium;
Biological process	hemostasis; cellular response to organic cyclic compound; G protein-coupled adenosine receptor signaling pathway; positive regulation of protein phosphorylation; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; eating behavior; positive regulation of cytosolic calcium ion concentration; response to mechanical stimulus; ageing; regulation of signaling receptor activity; negative regulation of norepinephrine secretion; signal transduction involved in regulation of gene expression; wound healing; G protein-coupled purinergic nucleotide receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; negative regulation of binding; positive regulation of ion transport; positive regulation of ERK1 and ERK2 cascade; sensory perception of pain; response to growth factor; positive regulation of penile erection; protein localization to plasma membrane; positive regulation of hormone secretion; relaxation of muscle; positive regulation of transcription by RNA polymerase II; glial cell migration; signal transduction; blood coagulation; platelet activation; blood vessel diameter maintenance; G protein-coupled receptor signaling pathway; regulation of cell shape; cellular response to ATP; cellular response to purine-containing compound; regulation of presynaptic cytosolic calcium ion concentration; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5028
	18441
	ENSG00000169860
	ENSMUSG00000027765
	P47900
	P49650
	NM_002563
	NM_001282016; NM_008772
	NP_002554
	NP_001268945; NP_032798
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027765 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169860 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027765 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8579591-5] Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.

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