P2RY4

P2RY4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B6Q
Identifiers
Aliases	P2RY4, NRU, P2P, P2Y4, UNR, pyrimidinergic receptor P2Y4
External IDs	OMIM: 300038; MGI: 1926594; HomoloGene: 20568; GeneCards: P2RY4; OMA:P2RY4 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	70,260,204 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	99,638,475 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; mucosa of ileum; ; optic nerve; ; deltoid muscle; ; skin of abdomen; ; rectum; ; skin of limb; ; skin of leg; ; skin of hip; ; transverse colon;
	Top expressed in
	esophagus; ; right ventricle; ; lip; ; tibiofemoral joint; ; digastric muscle; ; gastrula; ; carotid body; ; liver; ; jejunum; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled UTP receptor activity; ATP binding; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane; glutamatergic synapse; integral component of presynaptic active zone membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; phospholipase C-activating G protein-coupled receptor signaling pathway; transepithelial chloride transport; signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway; cellular response to prostaglandin E stimulus; G protein-coupled receptor signaling pathway; cellular response to ATP; regulation of presynaptic cytosolic calcium ion concentration; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	5030
	57385
	ENSG00000186912
	ENSMUSG00000044359
	P51582
	Q9JJS7
	NM_002565
	NM_020621
	NP_002556
	NP_065646
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.^[5]^[6]

The product of this gene, P2Y₄, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186912 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044359 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Communi D, Pirotton S, Parmentier M, Boeynaems JM (Feb 1996). "Cloning and functional expression of a human uridine nucleotide receptor". J Biol Chem. 270 (52): 30849–52. doi:10.1074/jbc.270.52.30849. PMID 8537336.
^ ^a ^b "Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186912 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8537336-5] Communi D, Pirotton S, Parmentier M, Boeynaems JM (Feb 1996). "Cloning and functional expression of a human uridine nucleotide receptor". J Biol Chem. 270 (52): 30849–52. doi:10.1074/jbc.270.52.30849. PMID 8537336.

[entrez-6] "Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4".

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