PAK3

PAK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EES
Identifiers
Aliases	PAK3, CDKN1A, MRX30, MRX47, OPHN3, PAK3beta, bPAK, hPAK-3, beta-PAK, ARA, p21 (RAC1) activated kinase 3, XLID30
External IDs	OMIM: 300142; MGI: 1339656; HomoloGene: 55664; GeneCards: PAK3; OMA:PAK3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	111,227,361 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	142,580,792 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; endothelial cell; ; entorhinal cortex; ; orbitofrontal cortex; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; lateral nuclear group of thalamus; ; Region I of hippocampus proper;
	Top expressed in
	ventromedial nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; anterior amygdaloid area; ; arcuate nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; SH3 domain binding; metal ion binding; kinase activity; protein binding; catalytic activity; GTPase binding; ATP binding; MAP kinase kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; cytosol; endosome; plasma membrane; postsynaptic density; glutamatergic synapse;
Biological process	regulation of neuron projection development; phosphorylation; ephrin receptor signaling pathway; dendrite development; T cell costimulation; synapse organization; cellular response to organic cyclic compound; stimulatory C-type lectin receptor signaling pathway; multicellular organism development; protein phosphorylation; regulation of actin filament polymerization; positive regulation of neuron apoptotic process; dendritic spine development; positive regulation of DNA biosynthetic process; metabolism; T cell receptor signaling pathway; positive regulation of dendritic spine morphogenesis; MAPK cascade; regulation of actin cytoskeleton organization; positive regulation of fibroblast migration; dendritic spine morphogenesis; Rho protein signal transduction; regulation of mitotic cell cycle; axonogenesis; cell migration; stress-activated protein kinase signaling cascade; regulation of axonogenesis; regulation of apoptotic process; signal transduction; activation of protein kinase activity; regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	5063
	18481
	ENSG00000077264
	ENSMUSG00000031284
	O75914
	Q61036
NM_001128166; NM_001128167; NM_001128168; NM_001128172; NM_001128173;
	NM_002578; NM_001324325; NM_001324326; NM_001324327; NM_001324328; NM_001324329; NM_001324330; NM_001324331; NM_001324332; NM_001324333; NM_001324334
	NM_001195046; NM_001195047; NM_001195048; NM_001195049; NM_008778
NP_001121638; NP_001121639; NP_001121640; NP_001121644; NP_001121645;
	NP_001311254; NP_001311255; NP_001311256; NP_001311257; NP_001311258; NP_001311259; NP_001311260; NP_001311261; NP_001311262; NP_001311263; NP_002569
	NP_001181975; NP_001181976; NP_001181977; NP_001181978; NP_032804
	Wikidata
View/Edit Human	View/Edit Mouse

PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases.^[5]^[6]^[7] PAK3 is preferentially expressed in neuronal cells ^[8]^[9] and involved in synapse formation and plasticity and mental retardation.^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077264 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031284 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM (July 1995). "Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors". Science. 269 (5221): 221–3. Bibcode:1995Sci...269..221K. doi:10.1126/science.7618083. PMID 7618083.
^ Manser E, Chong C, Zhao ZS, Leung T, Michael G, Hall C, Lim L (October 1995). "Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family". The Journal of Biological Chemistry. 270 (42): 25070–8. doi:10.1074/jbc.270.42.25070. PMID 7559638.
^ Kumar A, Molli PR, Pakala SB, Bui Nguyen TM, Rayala SK, Kumar R (July 2009). "PAK thread from amoeba to mammals". Journal of Cellular Biochemistry. 107 (4): 579–85. doi:10.1002/jcb.22159. PMC 2718766. PMID 19350548.
^ Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA (September 1995). "Identification of a mouse p21Cdc42/Rac activated kinase". The Journal of Biological Chemistry. 270 (39): 22731–7. doi:10.1074/jbc.270.39.22731. PMID 7559398.
^ Burbelo PD, Kozak CA, Finegold AA, Hall A, Pirone DM (May 1999). "Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes". Gene. 232 (2): 209–15. doi:10.1016/s0378-1119(99)00110-9. PMID 10352232.
^ Boda B, Alberi S, Nikonenko I, Node-Langlois R, Jourdain P, Moosmayer M, Parisi-Jourdain L, Muller D (December 2004). "The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus". The Journal of Neuroscience. 24 (48): 10816–25. doi:10.1523/jneurosci.2931-04.2004. PMC 6730202. PMID 15574732.
^ Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (September 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nature Genetics. 20 (1): 25–30. doi:10.1038/1675. PMID 9731525. S2CID 16041444.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077264 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031284 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM (July 1995). "Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors". Science. 269 (5221): 221–3. Bibcode:1995Sci...269..221K. doi:10.1126/science.7618083. PMID 7618083.

[6] Manser E, Chong C, Zhao ZS, Leung T, Michael G, Hall C, Lim L (October 1995). "Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family". The Journal of Biological Chemistry. 270 (42): 25070–8. doi:10.1074/jbc.270.42.25070. PMID 7559638.

[7] Kumar A, Molli PR, Pakala SB, Bui Nguyen TM, Rayala SK, Kumar R (July 2009). "PAK thread from amoeba to mammals". Journal of Cellular Biochemistry. 107 (4): 579–85. doi:10.1002/jcb.22159. PMC 2718766. PMID 19350548.

[RA-8] Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA (September 1995). "Identification of a mouse p21Cdc42/Rac activated kinase". The Journal of Biological Chemistry. 270 (39): 22731–7. doi:10.1074/jbc.270.39.22731. PMID 7559398.

[DM-9] Burbelo PD, Kozak CA, Finegold AA, Hall A, Pirone DM (May 1999). "Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes". Gene. 232 (2): 209–15. doi:10.1016/s0378-1119(99)00110-9. PMID 10352232.

[D-10] Boda B, Alberi S, Nikonenko I, Node-Langlois R, Jourdain P, Moosmayer M, Parisi-Jourdain L, Muller D (December 2004). "The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus". The Journal of Neuroscience. 24 (48): 10816–25. doi:10.1523/jneurosci.2931-04.2004. PMC 6730202. PMID 15574732.

[CA-11] Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (September 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nature Genetics. 20 (1): 25–30. doi:10.1038/1675. PMID 9731525. S2CID 16041444.

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