PARD6A

PARD6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMH
Identifiers
Aliases	PARD6A, PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40, par-6 family cell polarity regulator alpha
External IDs	OMIM: 607484; MGI: 1927223; HomoloGene: 9661; GeneCards: PARD6A; OMA:PARD6A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,662,774 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,430,128 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; prefrontal cortex; ; sperm; ; right frontal lobe; ; paraflocculus of cerebellum; ; right testis; ; glutes; ; frontal pole; ; left testis; ; triceps brachii muscle;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; spermatocyte; ; seminiferous tubule; ; spermatid; ; pontine nuclei; ; primary oocyte; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; GTP-dependent protein binding; protein binding; protein kinase C binding;
Cellular component	cytosol; cell projection; membrane; bicellular tight junction; ruffle; plasma membrane; cell cortex; nucleus; cytoplasm; centrosome; microtubule organizing center; cytoskeleton; cell junction; centriolar satellite; protein-containing complex; apical plasma membrane;
Biological process	negative regulation of protein phosphorylation; cell division; cell-cell junction maintenance; bicellular tight junction assembly; cell cycle; viral process; transforming growth factor beta receptor signaling pathway; Wnt signaling pathway, planar cell polarity pathway; positive regulation of protein localization to centrosome; centrosome cycle; establishment or maintenance of cell polarity; regulation of cellular localization; positive regulation of protein secretion;
	Sources:Amigo / QuickGO
Orthologs
	50855
	56513
	ENSG00000102981
	ENSMUSG00000005699
	Q9NPB6
	Q9Z101
	NM_001037281; NM_016948
	NM_001047435; NM_001047436; NM_001286344; NM_001286345; NM_019695
	NP_001032358; NP_058644
	NP_001040900; NP_001040901; NP_001273273; NP_001273274; NP_062669
	Wikidata
View/Edit Human	View/Edit Mouse

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102981 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.
^ Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
^ "Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102981 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9482110-5] Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene. 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110.

[pmid11260256-6] Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.

[entrez-7] "Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans)".

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