PARP3

PARP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Identifiers
Aliases	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
External IDs	OMIM: 607726; MGI: 1891258; HomoloGene: 4005; GeneCards: PARP3; OMA:PARP3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,948,867 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,354,148 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; apex of heart; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; muscle layer of sigmoid colon; ; transverse colon; ; stromal cell of endometrium;
	Top expressed in
	extraocular muscle; ; ankle; ; temporal muscle; ; triceps brachii muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; mesenteric lymph nodes; ; medial head of gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; catalytic activity; NAD+ ADP-ribosyltransferase activity; DNA ligase (ATP) activity; protein ADP-ribosylase activity; protein binding; NAD DNA ADP-ribosyltransferase activity;
Cellular component	cytoplasm; site of double-strand break; centriole; cytoskeleton; nucleus; microtubule organizing center; nucleolus; chromosome;
Biological process	protein localization to site of double-strand break; DNA ligation involved in DNA repair; lagging strand elongation; regulation of mitotic spindle organization; positive regulation of DNA ligation; telomere maintenance; double-strand break repair; protein ADP-ribosylation; DNA repair; negative regulation of telomerase RNA reverse transcriptase activity; protein poly-ADP-ribosylation; DNA ADP-ribosylation; negative regulation of isotype switching; protein auto-ADP-ribosylation; protein mono-ADP-ribosylation; positive regulation of double-strand break repair via nonhomologous end joining; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	10039
	235587
	ENSG00000041880
	ENSMUSG00000023249
	Q9Y6F1
	Q3ULW8
	NM_001003931; NM_001003935; NM_005485; NM_001370239; NM_001370240
	NM_145619; NM_001311150
	NP_001003931; NP_005476; NP_001357168; NP_001357169
	NP_001298079; NP_663594
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.^[5]^[6]

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000041880 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023249 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.
^ ^a ^b "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000041880 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023249 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10329013-5] Johansson M (Aug 1999). "A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues". Genomics. 57 (3): 442–5. doi:10.1006/geno.1999.5799. PMID 10329013.

[entrez-6] "Entrez Gene: PARP3 poly (ADP-ribose) polymerase family, member 3".

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