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Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.[5][6][7]
The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.[7]
- ^ a b c GRCh38: Ensembl release 89: 55872 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022033 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Abe Y, Matsumoto S, Kito K, Ueda N (Aug 2000). "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells". J Biol Chem. 275 (28): 21525–31. doi:10.1074/jbc.M909629199. PMID 10781613.
- ^ Gaudet S, Branton D, Lue RA (Jun 2000). "Characterization of PDZ-binding kinase, a mitotic kinase". Proc Natl Acad Sci U S A. 97 (10): 5167–72. Bibcode:2000PNAS...97.5167G. doi:10.1073/pnas.090102397. PMC 25800. PMID 10779557.
- ^ a b "Entrez Gene: PBK PDZ binding kinase".