PCGEM1

Prostate-specific transcript 1
Prostate-specific transcript 1
	Predicted secondary structure and sequence conservation of PCGEM1
Identifiers
Symbol	PCGEM1
Rfam	RF01981
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:0042981
SO	SO:0001463
PDB structures	PDBe

PCGEM1
Identifiers
Aliases	PCGEM1, LINC00071, NCRNA00071, PCAT9, prostate-specific transcript (non-protein coding), prostate-specific transcript, PCGEM1 prostate-specific transcript
External IDs	OMIM: 605443; GeneCards: PCGEM1; OMA:PCGEM1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	192,776,899 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prostate; ; epithelium of colon; ; prefrontal cortex; ; monocyte; ; reproductive organ; ; amygdala; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; primary visual cortex;
	n/a
	More reference expression data
	n/a
Orthologs
	64002
	n/a
	ENSG00000227418
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer.^[3]^[4] In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.^[5]

PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000227418 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Srikantan V, Zou Z, Petrovics G, et al. (October 2000). "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. Bibcode:2000PNAS...9712216S. doi:10.1073/pnas.97.22.12216. PMC 17321. PMID 11050243.
^ Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H (February 2006). "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol. 13 (1): 2967–2974. PMID 16515751.
^ Petrovics G, Zhang W, Makarem M, et al. (January 2004). "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene. 23 (2): 605–611. doi:10.1038/sj.onc.1207069. PMID 14724589.
^ Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (March 2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. doi:10.1089/dna.2006.25.135. PMID 16569192.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000227418 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050243-3] Srikantan V, Zou Z, Petrovics G, et al. (October 2000). "PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 12216–12221. Bibcode:2000PNAS...9712216S. doi:10.1073/pnas.97.22.12216. PMC 17321. PMID 11050243.

[pmid16515751-4] Bialkowska-Hobrzanska H, Driman DK, Fletcher R, Harry V, Razvi H (February 2006). "Expression of human telomerase reverse transcriptase, Survivin, DD3 and PCGEM1 messenger RNA in archival prostate carcinoma tissue". Can J Urol. 13 (1): 2967–2974. PMID 16515751.

[pmid14724589-5] Petrovics G, Zhang W, Makarem M, et al. (January 2004). "Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients". Oncogene. 23 (2): 605–611. doi:10.1038/sj.onc.1207069. PMID 14724589.

[pmid16569192-6] Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S (March 2006). "Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1". DNA Cell Biol. 25 (3): 135–141. doi:10.1089/dna.2006.25.135. PMID 16569192.

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