PCK1

PCK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Identifiers
Aliases	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
External IDs	OMIM: 614168; MGI: 97501; HomoloGene: 1944; GeneCards: PCK1; OMA:PCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,568,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,001,066 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; glomerulus; ; metanephric glomerulus; ; kidney tubule; ; human kidney; ; mucosa of colon; ; renal medulla; ; mucosa of sigmoid colon; ; mucosa of ileum;
	Top expressed in
	right kidney; ; brown adipose tissue; ; human kidney; ; left lobe of liver; ; white adipose tissue; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; intercostal muscle; ; mammary gland; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; manganese ion binding; GDP binding; phosphoenolpyruvate carboxykinase activity; GTP binding; metal ion binding; carboxylic acid binding; purine nucleotide binding; lyase activity; carboxy-lyase activity; magnesium ion binding; phosphoenolpyruvate carboxykinase (GTP) activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	glucose homeostasis; internal protein amino acid acetylation; lipid metabolism; response to activity; positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; oxaloacetate metabolic process; response to insulin; glyceroneogenesis; cellular response to potassium ion starvation; cellular response to retinoic acid; response to lipid; cellular response to hypoxia; cellular response to fructose stimulus; response to interleukin-6; glucose metabolic process; ageing; response to methionine; cellular response to interleukin-1; cellular response to glucagon stimulus; cellular response to cAMP; cellular response to insulin stimulus; cellular response to tumor necrosis factor; response to lipopolysaccharide; gluconeogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5105
	18534
	ENSG00000124253
	ENSMUSG00000027513
	P35558
	Q9Z2V4
	NM_002591
	NM_011044
	NP_002582
	NP_035174
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124253 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027513 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".
^ Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743. S2CID 23586336.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124253 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027513 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".

[pmid1492743-6] Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743. S2CID 23586336.

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