PCK2

PCK2
Identifiers
Aliases	PCK2, PEPCK, PEPCK-M, PEphosphoenolpyruvate carboxykinase 2, mitochondrial
External IDs	OMIM: 614095; MGI: 1860456; HomoloGene: 3356; GeneCards: PCK2; OMA:PCK2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,110,598 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,788,699 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; rectum; ; gastric mucosa; ; body of pancreas; ; granulocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; monocyte; ; appendix;
	Top expressed in
	calvaria; ; seminal vesicula; ; lacrimal gland; ; islet of Langerhans; ; salivary gland; ; fetal liver hematopoietic progenitor cell; ; molar; ; submandibular gland; ; body of femur; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; carboxy-lyase activity; purine nucleotide binding; metal ion binding; lyase activity; phosphoenolpyruvate carboxykinase activity; phosphoenolpyruvate carboxykinase (GTP) activity; manganese ion binding;
Cellular component	mitochondrial matrix; mitochondrion; cytosol;
Biological process	gluconeogenesis; positive regulation of insulin secretion; response to lipopolysaccharide; cellular response to tumor necrosis factor; oxaloacetate metabolic process; pyruvate metabolic process; NADH oxidation; response to dexamethasone; cellular response to glucose stimulus; propionate catabolic process; cellular response to insulin stimulus; response to lipid; response to starvation; glyceroneogenesis; hepatocyte differentiation; cellular response to dexamethasone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5106
	74551
	ENSG00000100889; ENSG00000285241
	ENSMUSG00000040618
	Q16822
	Q8BH04
	NM_001018073; NM_001291556; NM_001308054; NM_004563
	NM_028994
	NP_001018083; NP_001278485; NP_001294983; NP_004554
	NP_083270
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoenolpyruvate carboxykinase 2, mitochondrial (PCK2, PEPCK-M), is an isozyme of phosphoenolpyruvate carboxykinase (PCK, PEPCK) that in humans is encoded by the PCK2 gene on chromosome 14. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2014]^[5]

^ ^a ^b ^c ENSG00000285241 GRCh38: Ensembl release 89: ENSG00000100889, ENSG00000285241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040618 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)". NCBI Entrez Gene database.

[refGRCh38Ensembl-1] ENSG00000285241 GRCh38: Ensembl release 89: ENSG00000100889, ENSG00000285241 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040618 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)". NCBI Entrez Gene database.

[1]

[2]

[3]

[4]

[5]