Protein-coding gene in the species Homo sapiens
Pericentrin (kendrin ), also known as PCNT and pericentrin-B (PCNTB ), is a protein which in humans is encoded by the PCNT gene on chromosome 21.[ 5] [ 6] [ 7] [ 8] localizes to the centrosome and recruits proteins to the pericentriolar matrix (PCM) to ensure proper centrosome and mitotic spindle formation, and thus, uninterrupted cell cycle progression.[ 5] [ 9] [ 10] [ 11] [ 12] diseases and disorders , including congenital disorders such as microcephalic osteodysplastic primordial dwarfism type II (MOPDII) and Seckel syndrome .[ 9] [ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000160299 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001151 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: PCNT pericentrin (kendrin)" .^ Chen H, Gos A, Morris MA, Antonarakis SE (Aug 1996). "Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter". Genomics . 35 (3): 620–4. doi :10.1006/geno.1996.0411 . PMID 8812505 . ^ Flory MR, Moser MJ, Monnat RJ, Davis TN (May 2000). "Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin" . Proceedings of the National Academy of Sciences of the United States of America . 97 (11): 5919–23. Bibcode :2000PNAS...97.5919F . doi :10.1073/pnas.97.11.5919 PMC 18534 PMID 10823944 . ^ Li Q, Hansen D, Killilea A, Joshi HC, Palazzo RE, Balczon R (Feb 2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1". Journal of Cell Science . 114 (Pt 4): 797–809. doi :10.1242/jcs.114.4.797 . PMID 11171385 . ^ a b Liu Q, Yu J, Zhuo X, Jiang Q, Zhang C (Aug 2010). "Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle" . Cell Research . 20 (8): 948–62. doi :10.1038/cr.2010.89 PMID 20567258 . ^ a b Kim S, Rhee K (2014). "Importance of the CEP215-pericentrin interaction for centrosome maturation during mitosis" . PLOS ONE . 9 (1): e87016. Bibcode :2014PLoSO...987016K . doi :10.1371/journal.pone.0087016 PMC 3899370 PMID 24466316 . ^ Huang-Doran I, Bicknell LS, Finucane FM, Rocha N, Porter KM, Tung YC, Szekeres F, Krook A, Nolan JJ, O'Driscoll M, Bober M, O'Rahilly S, Jackson AP, Semple RK (Mar 2011). "Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes" . Diabetes . 60 (3): 925–35. doi :10.2337/db10-1334 . PMC 3046854 PMID 21270239 . ^ Shimizu S, Matsuzaki S, Hattori T, Kumamoto N, Miyoshi K, Katayama T, Tohyama M (Dec 2008). "DISC1-kendrin interaction is involved in centrosomal microtubule network formation". Biochemical and Biophysical Research Communications . 377 (4): 1051–6. doi :10.1016/j.bbrc.2008.10.100 . PMID 18955030 . 
