PCSK4

PCSK4
Identifiers
Aliases	PCSK4, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487; MGI: 97514; HomoloGene: 22495; GeneCards: PCSK4; OMA:PCSK4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,490,752 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,329,498 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right uterine tube; ; testicle; ; anterior pituitary; ; right lobe of liver; ; right frontal lobe; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; olfactory zone of nasal mucosa;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; neural layer of retina; ; outer nuclear layer; ; embryo; ; proximal tubule; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; protein binding; serine-type endopeptidase activity;
Cellular component	integral component of membrane; membrane; acrosomal membrane; cytoplasmic vesicle; acrosomal vesicle; trans-Golgi network; integral component of Golgi membrane;
Biological process	proteolysis; binding of sperm to zona pellucida; sperm capacitation; acrosome reaction; fertilization; reproductive process; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
	54760
	18551
	ENSG00000115257
	ENSMUSG00000020131
	Q6UW60
	P29121
	NM_017573; NM_001395257
	NM_008793
	NP_060043
	NP_032819
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.
^ "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115257 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020131 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7782070-5] Mbikay M, Seidah NG, Chretien M, Simpson EM (Jul 1995). "Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human". Genomics. 26 (1): 123–9. doi:10.1016/0888-7543(95)80090-9. PMID 7782070.

[entrez-6] "Entrez Gene: PCSK4 proprotein convertase subtilisin/kexin type 4".

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