PFKFB3

PFKFB3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2AXN, 2DWO, 2DWP, 2I1V, 3QPU, 3QPV, 3QPW, 4MA4, 5AJV, 5AJW, 5AJX, 5AJY, 5AJZ, 5AK0, 4D4K, 4D4M, 4D4L, 4D4J
Identifiers
Aliases	PFKFB3, IPFK2, PFK2, iPFK-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
External IDs	OMIM: 605319; MGI: 2181202; HomoloGene: 88708; GeneCards: PFKFB3; OMA:PFKFB3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	6,254,644 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	11,558,888 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; renal medulla; ; endothelial cell; ; subcutaneous adipose tissue; ; internal globus pallidus; ; gastrocnemius muscle; ; lower lobe of lung; ; periodontal fiber; ; external globus pallidus; ; gastric mucosa;
	Top expressed in
	medial head of gastrocnemius muscle; ; triceps brachii muscle; ; temporal muscle; ; brown adipose tissue; ; subcutaneous adipose tissue; ; white adipose tissue; ; vastus lateralis muscle; ; mesenteric lymph nodes; ; tunica adventitia of aorta; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; fructose-2,6-bisphosphate 2-phosphatase activity; catalytic activity; hydrolase activity; ATP binding; kinase activity; 6-phosphofructo-2-kinase activity;
Cellular component	cytosol; nucleoplasm;
Biological process	fructose metabolic process; metabolism; brain development; fructose 2,6-bisphosphate metabolic process; phosphorylation; dephosphorylation; carbohydrate phosphorylation; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5209
	170768
	ENSG00000170525
	ENSMUSG00000026773
	Q16875; Q9BQU1
	n/a
NM_001145443; NM_001282630; NM_001314063; NM_004566; NM_001323016;
	NM_001323017; NM_001363545
NM_001177752; NM_001177753; NM_001177754; NM_001177755; NM_001177756;
	NM_001177757; NM_001177758; NM_133232; NM_172976
NP_001138915; NP_001269559; NP_001300992; NP_001309945; NP_001309946;
	NP_004557; NP_001350474
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

PFKFB3 is a gene that encodes the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 enzyme in humans.^[5]^[6]^[7] It is one of 4 tissue-specific PFKFB isoenzymes identified currently (PFKFB1-4).^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170525 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026773 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nicholl J, Hamilton JA, Sutherland GR, Sutherland RL, Watts CK (April 1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Research. 5 (2): 150. doi:10.1023/A:1018482511456. PMID 9146922. S2CID 34088792.
^ Manzano A, Rosa JL, Ventura F, Pérez JX, Nadal M, Estivill X, et al. (Mar 1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenetics and Cell Genetics. 83 (3–4): 214–7. doi:10.1159/000015181. PMID 10072580. S2CID 23221556.
^ "Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3".
^ Mahlknecht U, Chesney J, Hoelzer D, Bucala R (October 2003). "Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)". International Journal of Oncology. 23 (4): 883–91. doi:10.3892/ijo.23.4.883. PMID 12963966.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170525 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026773 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9146922-5] Nicholl J, Hamilton JA, Sutherland GR, Sutherland RL, Watts CK (April 1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Research. 5 (2): 150. doi:10.1023/A:1018482511456. PMID 9146922. S2CID 34088792.

[pmid10072580-6] Manzano A, Rosa JL, Ventura F, Pérez JX, Nadal M, Estivill X, et al. (Mar 1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenetics and Cell Genetics. 83 (3–4): 214–7. doi:10.1159/000015181. PMID 10072580. S2CID 23221556.

[entrez-7] "Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3".

[:0-8] Mahlknecht U, Chesney J, Hoelzer D, Bucala R (October 2003). "Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)". International Journal of Oncology. 23 (4): 883–91. doi:10.3892/ijo.23.4.883. PMID 12963966.

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