PIGC

PIGC
Identifiers
Aliases	PIGC, GPI2, phosphatidylinositol glycan anchor biosynthesis class C, MRT62, GPIBD16
External IDs	OMIM: 601730; MGI: 1914542; HomoloGene: 7109; GeneCards: PIGC; OMA:PIGC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,444,086 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,801,004 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; skin of leg; ; skin of abdomen; ; islet of Langerhans; ; monocyte; ; skin of thigh; ; nipple; ; body of pancreas; ; bone marrow; ; hair follicle;
	Top expressed in
	seminal vesicula; ; cornea; ; renal corpuscle; ; calvaria; ; epithelium of lens; ; temporal muscle; ; upper arm; ; molar; ; primary oocyte; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; catalytic activity; glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; endoplasmic reticulum; membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane;
	Sources:Amigo / QuickGO
Orthologs
	5279
	67292
	ENSG00000135845
	ENSMUSG00000026698
	Q92535
	Q9CXR4
	NM_153747; NM_002642
	NM_001039045; NM_026078
	NP_002633; NP_714969
	NP_001034134; NP_080354
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.^[5]^[6]^[7]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135845 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.
^ Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics. 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.
^ ^a ^b "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135845 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8806613-5] Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.

[pmid9325057-6] Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics. 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.

[entrez-7] "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C".

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