PIKFYVE

PIKFYVE
Identifiers
Aliases	PIKFYVE, CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29, phosphoinositide kinase, FYVE-type zinc finger containing
External IDs	OMIM: 609414; MGI: 1335106; HomoloGene: 32115; GeneCards: PIKFYVE; OMA:PIKFYVE - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	208,358,746 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	65,317,854 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Epithelium of choroid plexus; ; seminal vesicula; ; corpus epididymis; ; cartilage tissue; ; tibia; ; Achilles tendon; ; tail of epididymis; ; jejunal mucosa; ; bone marrow;
	Top expressed in
	Rostral migratory stream; ; ciliary body; ; stroma of bone marrow; ; retinal pigment epithelium; ; iris; ; Epithelium of choroid plexus; ; cumulus cell; ; granulocyte; ; granular layer; ; pineal gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; zinc ion binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; metal ion binding; kinase activity; protein binding; phosphatidylinositol phosphate kinase activity; ATP binding; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; 1-phosphatidylinositol-3-phosphate 5-kinase activity; protein folding chaperone activity; unfolded protein binding;
Cellular component	cytosol; endosome; early endosome membrane; membrane; late endosome membrane; cell-cell junction; vesicle membrane; Golgi membrane; perinuclear region of cytoplasm; membrane raft; endosome membrane; cytoplasmic vesicle;
Biological process	intracellular signal transduction; phosphatidylinositol metabolic process; phosphorylation; myelin assembly; receptor-mediated endocytosis; regulation of autophagosome assembly; phosphatidylinositol phosphate biosynthetic process; retrograde transport, endosome to Golgi; phosphatidylinositol 5-phosphate metabolic process; protein localization to nucleus; phosphatidylinositol biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; 'de novo' protein folding; chaperone-mediated protein folding; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	200576
	18711
	ENSG00000115020
	ENSMUSG00000025949
	Q9Y2I7
	Q9Z1T6
	NM_001002881; NM_001178000; NM_015040; NM_152671
	NM_011086; NM_001310624
	NP_001171471; NP_055855; NP_689884
	NP_001297553; NP_035216
	Wikidata
View/Edit Human	View/Edit Mouse

PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115020 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025949 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Cite error: The named reference Shisheva_1999 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115020 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025949 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[Shisheva_1999-6] Cite error: The named reference Shisheva_1999 was invoked but never defined (see the help page).

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