PIM3

PIM3
Identifiers
Aliases	PIM3, pim-3, Pim-3 proto-oncogene, serine/threonine kinase
External IDs	OMIM: 610580; MGI: 1355297; HomoloGene: 56955; GeneCards: PIM3; OMA:PIM3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	49,964,072 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	88,749,929 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; skin of abdomen; ; skin of leg; ; body of stomach; ; upper lobe of left lung; ; minor salivary glands; ; left uterine tube; ; subcutaneous adipose tissue; ; right lung; ; gastrocnemius muscle;
	Top expressed in
	Paneth cell; ; lacrimal gland; ; vestibular membrane of cochlear duct; ; cumulus cell; ; parotid gland; ; motor neuron; ; facial motor nucleus; ; substantia nigra; ; endothelial cell of lymphatic vessel; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; cytosol;
Biological process	protein autophosphorylation; protein phosphorylation; cell cycle; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of apoptotic process; phosphorylation; regulation of mitotic cell cycle; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	415116
	223775
	ENSG00000198355
	ENSMUSG00000035828
	Q86V86
	P58750
	NM_001001852
	NM_145478
	NP_001001852
	NP_663453
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase pim-3 is an enzyme that in humans is encoded by the PIM3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035828 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Atalay P, Ozpolat B (January 2024). "PIM3 Kinase: A Promising Novel Target in Solid Cancers". Cancers. 16 (3): 535. doi:10.3390/cancers16030535. PMC 10854964. PMID 38339286.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035828 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid38339286-5] Atalay P, Ozpolat B (January 2024). "PIM3 Kinase: A Promising Novel Target in Solid Cancers". Cancers. 16 (3): 535. doi:10.3390/cancers16030535. PMC 10854964. PMID 38339286.

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