PIN1

PIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F8A, 1I6C, 1I8G, 1I8H, 1NMV, 1NMW, 1PIN, 1ZCN, 2F21, 2ITK, 2KBU, 2KCF, 2LB3, 2M8I, 2M8J, 2M9E, 2M9F, 2M9I, 2M9J, 2Q5A, 2RUC, 2RUD, 2XP3, 2XP4, 2XP5, 2XP6, 2XP7, 2XP8, 2XP9, 2XPA, 2XPB, 2ZQS, 2ZQT, 2ZQU, 2ZQV, 2ZR4, 2ZR5, 2ZR6, 3I6C, 3IK8, 3IKD, 3IKG, 3JYJ, 3KAB, 3KAC, 3KAD, 3KAF, 3KAG, 3KAH, 3KAI, 3KCE, 3NTP, 3ODK, 3OOB, 3TC5, 3TCZ, 3TDB, 3WH0, 4GWT, 4GWV, 4QIB, 4TNS, 4TYO, 4U84, 4U85, 4U86, 2RUQ, 2N1O, 2RUR
Identifiers
Aliases	PIN1, DOD, UBL5, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
External IDs	OMIM: 601052; MGI: 1346036; HomoloGene: 4531; GeneCards: PIN1; OMA:PIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	9,849,689 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,577,880 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; frontal pole; ; prefrontal cortex; ; anterior cingulate cortex; ; right testis; ; dorsolateral prefrontal cortex; ; left testis; ; right hemisphere of cerebellum; ; Brodmann area 9; ; nucleus accumbens;
	Top expressed in
	primary motor cortex; ; anterior amygdaloid area; ; somite; ; cingulate gyrus; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; lateral septal nucleus; ; soleus muscle; ; prefrontal cortex; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activating protein binding; beta-catenin binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; mitogen-activated protein kinase kinase binding; cytoskeletal motor activity; phosphoserine residue binding; phosphothreonine residue binding; tau protein binding; phosphoprotein binding; cis-trans isomerase activity;
Cellular component	cytoplasm; cytosol; nuclear speck; midbody; mitochondrion; neuron projection; nucleus; nucleoplasm; glutamatergic synapse; postsynaptic cytosol;
Biological process	negative regulation of neuron apoptotic process; positive regulation of protein phosphorylation; regulation of cytokinesis; positive regulation of protein dephosphorylation; negative regulation of protein catabolic process; positive regulation of canonical Wnt signaling pathway; synapse organization; negative regulation of cell motility; protein stabilization; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of protein binding; protein peptidyl-prolyl isomerization; regulation of protein localization to nucleus; positive regulation of GTPase activity; positive regulation of neuron apoptotic process; positive regulation of ubiquitin-protein transferase activity; neuron differentiation; negative regulation of ERK1 and ERK2 cascade; cell cycle; negative regulation of type I interferon production; positive regulation of cell growth involved in cardiac muscle cell development; regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription by RNA polymerase II; regulation of mitotic nuclear division; regulation of signal transduction by p53 class mediator; regulation of protein phosphorylation; regulation of gene expression; positive regulation of protein binding; microtubule polymerization; response to hypoxia; regulation of protein stability; negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologs
	5300
	23988
	ENSG00000127445
	ENSMUSG00000032171
	Q13526
	Q9QUR7
	NM_006221
	NM_023371; NM_001364495
	NP_006212
	NP_075860; NP_001351424
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.^[5]^[6]

Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer^[7]^[8] and immune disorders.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127445 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032171 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lu KP, Hanes SD, Hunter T (Apr 1996). "A human peptidyl-prolyl isomerase essential for regulation of mitosis". Nature. 380 (6574): 544–7. Bibcode:1996Natur.380..544P. doi:10.1038/380544a0. PMID 8606777. S2CID 4258406.
^ "Entrez Gene: PIN1 Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1".
^ da Costa KS, Galúcio JM, de Jesus DA, Gomes GC, Lima e Lima AH, Taube PS, dos Santos AM, Lameira J (2019-10-25). "Targeting Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1: A Structure-based Virtual Screening Approach to Find Novel Inhibitors". Current Computer-Aided Drug Design. 15 (5): 605–617. doi:10.2174/1573409915666191025114009. PMID 31654518. S2CID 204907887.
^ Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B (August 2017). "A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action". Nature Communications. 8 (1): 15772. Bibcode:2017NatCo...815772C. doi:10.1038/ncomms15772. ISSN 2041-1723. PMC 5472749. PMID 28598431.
^ Rudrabhatla P, Albers W, Pant HC (2009-11-25). "Peptidyl-Prolyl Isomerase 1 Regulates Protein Phosphatase 2A-Mediated Topographic Phosphorylation of Neurofilament Proteins". Journal of Neuroscience. 29 (47): 14869–14880. doi:10.1523/JNEUROSCI.4469-09.2009. ISSN 0270-6474. PMC 3849796. PMID 19940183.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127445 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032171 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8606777-5] Lu KP, Hanes SD, Hunter T (Apr 1996). "A human peptidyl-prolyl isomerase essential for regulation of mitosis". Nature. 380 (6574): 544–7. Bibcode:1996Natur.380..544P. doi:10.1038/380544a0. PMID 8606777. S2CID 4258406.

[6] "Entrez Gene: PIN1 Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1".

[7] Costa KS, Galúcio JM, de Jesus DA, Gomes GC, Lima e Lima AH, Taube PS, dos Santos AM, Lameira J (2019-10-25). "Targeting Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1: A Structure-based Virtual Screening Approach to Find Novel Inhibitors". Current Computer-Aided Drug Design. 15 (5): 605–617. doi:10.2174/1573409915666191025114009. PMID 31654518. S2CID 204907887.

[8] Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B (August 2017). "A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action". Nature Communications. 8 (1): 15772. Bibcode:2017NatCo...815772C. doi:10.1038/ncomms15772. ISSN 2041-1723. PMC 5472749. PMID 28598431.

[9] Rudrabhatla P, Albers W, Pant HC (2009-11-25). "Peptidyl-Prolyl Isomerase 1 Regulates Protein Phosphatase 2A-Mediated Topographic Phosphorylation of Neurofilament Proteins". Journal of Neuroscience. 29 (47): 14869–14880. doi:10.1523/JNEUROSCI.4469-09.2009. ISSN 0270-6474. PMC 3849796. PMID 19940183.

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