PINK1

PINK1
Identifiers
Aliases	PINK1, BRPK, PARK6, PTEN induced putative kinase 1, PTEN induced kinase 1
External IDs	OMIM: 608309; MGI: 1916193; HomoloGene: 32672; GeneCards: PINK1; OMA:PINK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,633,458 bp[1] End 20,651,511 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 138,040,720 bp[2] End 138,053,618 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii glutes gastrocnemius muscle right frontal lobe prefrontal cortex amygdala muscle of thigh apex of heart putamen nucleus accumbens Top expressed in muscle of thigh myocardium of ventricle intercostal muscle sciatic nerve digastric muscle triceps brachii muscle ankle sternocleidomastoid muscle temporal muscle extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C3HC4-type RING finger domain binding kinase activity ATP binding protein kinase activity metal ion binding protein serine/threonine kinase activity calcium-dependent protein kinase activity peptidase activator activity magnesium ion binding transferase activity protease binding protein binding nucleotide binding protein kinase B binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol membrane mitochondrial intermembrane space mitochondrion perinuclear region of cytoplasm cytoskeleton nucleus Lewy body integral component of mitochondrial outer membrane mitochondrial outer membrane chromatin TORC2 complex integral component of membrane ubiquitin ligase complex mitochondrial outer membrane translocase complex astrocyte projection axon cell body mitochondrial inner membrane growth cone Biological process negative regulation of neuron apoptotic process positive regulation of mitophagy in response to mitochondrial depolarization positive regulation of free ubiquitin chain polymerization regulation of protein ubiquitination cellular response to toxic substance positive regulation of catecholamine secretion regulation of synaptic vesicle transport positive regulation of translation protein phosphorylation positive regulation of dopamine secretion macroautophagy regulation of protein-containing complex assembly cellular response to hypoxia negative regulation of autophagosome assembly positive regulation of protein kinase B signaling positive regulation of protein dephosphorylation ubiquitin-dependent protein catabolic process peptidyl-serine autophosphorylation regulation of neuron apoptotic process response to oxidative stress negative regulation of gene expression positive regulation of peptidyl-serine phosphorylation negative regulation of mitochondrial fission positive regulation of mitochondrial electron transport, NADH to ubiquinone positive regulation of macroautophagy regulation of autophagy of mitochondrion positive regulation of ubiquitin-protein transferase activity negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway protein ubiquitination negative regulation of oxidative stress-induced cell death negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of synaptic transmission, dopaminergic negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of oxidative phosphorylation regulation of mitochondrion organization regulation of hydrogen peroxide metabolic process negative regulation of oxidative stress-induced neuron death protein stabilization mitochondrion organization positive regulation of DNA-binding transcription factor activity negative regulation of autophagy of mitochondrion regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process maintenance of protein location in mitochondrion regulation of protein targeting to mitochondrion positive regulation of release of cytochrome c from mitochondria respiratory electron transport chain positive regulation of protein ubiquitination regulation of proteasomal protein catabolic process activation of protein kinase B activity intracellular signal transduction negative regulation of macroautophagy positive regulation of protein targeting to mitochondrion positive regulation of cristae formation positive regulation of peptidase activity TORC2 signaling regulation of mitochondrial membrane potential autophagy negative regulation of JNK cascade establishment of protein localization to mitochondrion autophagy of mitochondrion peptidyl-serine phosphorylation positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to oxidative stress negative regulation of reactive oxygen species metabolic process negative regulation of apoptotic process positive regulation of protein phosphorylation positive regulation of histone deacetylase activity mitochondrion to lysosome transport regulation of cellular response to oxidative stress response to ischemia positive regulation of mitochondrial fission positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization cellular response to hydrogen sulfide phosphorylation negative regulation of neuron death positive regulation of NMDA glutamate receptor activity negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65018 68943 Ensembl ENSG00000158828 ENSMUSG00000028756 UniProt Q9BXM7 Q99MQ3 RefSeq (mRNA) NM_032409 NM_026880 RefSeq (protein) NP_115785 NP_081156 Location (UCSC) Chr 1: 20.63 – 20.65 Mb Chr 4: 138.04 – 138.05 Mb PubMed search [3] [4]
Wikidata
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PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.^[5][6]

It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria.^[7][8] PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation.^[9] Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.^[10]