PITX2

PITX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L7F, 2L7M, 2LKX
Identifiers
Aliases	PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4
External IDs	OMIM: 601542; MGI: 109340; HomoloGene: 55454; GeneCards: PITX2; OMA:PITX2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 110,617,423 bp[1] End 110,642,123 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 57.84 cM Start 128,993,527 bp[2] End 129,013,240 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums biceps brachii gingival epithelium Skeletal muscle tissue of biceps brachii muscle of thigh Skeletal muscle tissue of rectus abdominis body of tongue gastrocnemius muscle vastus lateralis muscle pituitary gland Top expressed in tooth molar umbilical cord subthalamus mesoderm labioscrotal swelling abdominal wall mammillary body lateral plate mesoderm ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding protein homodimerization activity transcription cis-regulatory region binding sequence-specific DNA binding DNA binding transcription coactivator activity chromatin DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding ribonucleoprotein complex binding DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific transcription factor binding phosphoprotein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm transcription regulator complex nucleoplasm Biological process response to vitamin A female gonad development vascular associated smooth muscle cell differentiation regulation of transcription by RNA polymerase II skeletal muscle tissue development cell proliferation involved in outflow tract morphogenesis prolactin secreting cell differentiation in utero embryonic development pituitary gland development vasculogenesis regulation of cell population proliferation myoblast fusion hair cell differentiation spleen development regulation of transcription, DNA-templated transcription by RNA polymerase II embryonic camera-type eye development ventricular septum morphogenesis endodermal digestive tract morphogenesis determination of left/right symmetry cardiac muscle tissue development positive regulation of transcription, DNA-templated subthalamic nucleus development ventricular cardiac muscle cell development left/right axis specification hypothalamus cell migration animal organ morphogenesis regulation of cell migration heart development embryonic digestive tract morphogenesis branching involved in blood vessel morphogenesis cardiac muscle cell differentiation digestive system development multicellular organism development atrioventricular valve development pulmonary vein morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis embryonic hindlimb morphogenesis lung development superior vena cava morphogenesis positive regulation of DNA binding extraocular skeletal muscle development pulmonary myocardium development deltoid tuberosity development atrial cardiac muscle tissue morphogenesis male gonad development anatomical structure morphogenesis brain development neuron differentiation odontogenesis of dentin-containing tooth Wnt signaling pathway left lung morphogenesis somatotropin secreting cell differentiation positive regulation of myoblast proliferation camera-type eye development response to hormone odontogenesis iris morphogenesis neuron migration negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5308 18741 Ensembl ENSG00000164093 ENSMUSG00000028023 UniProt Q99697 P97474 RefSeq (mRNA) NM_000325 NM_001204397 NM_001204398 NM_001204399 NM_153426 NM_153427 NM_001042502 NM_001042504 NM_001286942 NM_001287048 NM_011098 RefSeq (protein) NP_000316 NP_001191326 NP_001191327 NP_001191328 NP_700475 NP_700476 NP_001035967 NP_001035969 NP_001273871 NP_001273977 NP_035228 Location (UCSC) Chr 4: 110.62 – 110.64 Mb Chr 3: 128.99 – 129.01 Mb PubMed search [3] [4]
Wikidata
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Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene.^[5][6][7]