POLD3

POLD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U76, 3E0J, 2N1G
Identifiers
Aliases	POLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
External IDs	OMIM: 611415; MGI: 1915217; HomoloGene: 38202; GeneCards: POLD3; OMA:POLD3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	74,669,117 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,770,772 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; testicle; ; sperm; ; ganglionic eminence; ; rectum; ; gonad; ; monocyte; ; kidney tubule; ; bronchial epithelial cell;
	Top expressed in
	secondary oocyte; ; zygote; ; tail of embryo; ; primary oocyte; ; genital tubercle; ; spermatid; ; morula; ; somite; ; primitive streak; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA-directed DNA polymerase activity;
Cellular component	delta DNA polymerase complex; nucleus; nucleoplasm; cytoplasm;
Biological process	nucleotide-excision repair, DNA gap filling; DNA synthesis involved in DNA repair; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; telomere maintenance; DNA-dependent DNA replication; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; cellular response to DNA damage stimulus; telomere maintenance via semi-conservative replication; DNA mismatch repair; DNA strand elongation involved in DNA replication; DNA synthesis involved in UV-damage excision repair;
	Sources:Amigo / QuickGO
Orthologs
	10714
	67967
	ENSG00000077514
	ENSMUSG00000030726
	Q15054
	Q9EQ28
	NM_006591; NM_001363597
	NM_133692; NM_001368380
	NP_006582; NP_001350526
	NP_598453; NP_001355309
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.^[5]^[6] It is a component of the DNA polymerase delta complex.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077514 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.
^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077514 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030726 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10219083-5] Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.

[entrez-6] "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".

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