POLR1C

POLR1C
Identifiers
Aliases	POLR1C, RPA39, RPA40, RPA5, RPAC1, TCS3, AC40, RPC40, HLD11, polymerase (RNA) I subunit C, RNA polymerase I subunit C, RNA polymerase I and III subunit C
External IDs	OMIM: 610060; MGI: 103288; HomoloGene: 3586; GeneCards: POLR1C; OMA:POLR1C - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,562,419 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,558,980 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; pancreatic ductal cell; ; Achilles tendon; ; gonad; ; islet of Langerhans; ; right uterine tube; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; epithelium of nasopharynx;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; renal corpuscle; ; ureter; ; fossa; ; condyle; ; medial ganglionic eminence; ; maxillary prominence; ; mandibular prominence; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; RNA polymerase III activity; DNA-directed 5'-3' RNA polymerase activity; protein binding; RNA polymerase I activity;
Cellular component	cytosol; nucleoplasm; RNA polymerase III complex; nucleus; RNA polymerase I complex;
Biological process	transcription by RNA polymerase I; termination of RNA polymerase I transcription; epigenetic maintenance of chromatin in transcription-competent conformation; transcription initiation from RNA polymerase I promoter; transcription, DNA-templated; transcription by RNA polymerase III; transcription elongation from RNA polymerase I promoter; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	9533
	20016
	ENSG00000171453
	ENSMUSG00000067148
	O15160
	P52432
	NM_004875; NM_203290; NM_001318876; NM_001363658
	NM_009085
	NP_001305805; NP_976035; NP_001350587
	NP_033111
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerases I and III subunit RPAC1 is a protein that in humans is encoded by the POLR1C gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.
^ "Entrez Gene: POLR1C polymerase (RNA) I polypeptide C, 30kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[pmid12446911-6] Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.

[entrez-7] "Entrez Gene: POLR1C polymerase (RNA) I polypeptide C, 30kDa".

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