PORCN

PORCN
Identifiers
Aliases	PORCN, DHOF, FODH, MG61, PORC, PPN, porcupine homolog (Drosophila), porcupine O-acyltransferase
External IDs	OMIM: 300651; MGI: 1890212; HomoloGene: 41529; GeneCards: PORCN; OMA:PORCN - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	48,520,814 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	8,072,764 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; stromal cell of endometrium; ; anterior cingulate cortex; ; right auricle; ; prefrontal cortex; ; granulocyte; ; apex of heart;
	Top expressed in
	primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; superior frontal gyrus; ; cerebellar cortex; ; neural layer of retina; ; morula; ; lip; ; urethra; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; Wnt-protein binding; acyltransferase activity; palmitoleoyltransferase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; AMPA glutamate receptor complex; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; glutamatergic synapse;
Biological process	canonical Wnt signaling pathway; protein lipidation; glycoprotein metabolic process; Wnt signaling pathway; protein palmitoleylation; regulation of postsynaptic membrane neurotransmitter receptor levels;
	Sources:Amigo / QuickGO
Orthologs
	64840
	53627
	ENSG00000102312
	ENSMUSG00000031169
	Q9H237
	Q9JJJ7
NM_001282167; NM_022825; NM_203473; NM_203474; NM_203475;
	NM_203476
	NM_016913; NM_023638; NM_145907; NM_145908; NM_001308474
	NP_001269096; NP_073736; NP_982299; NP_982300; NP_982301
	NP_001295403; NP_058609; NP_076127; NP_665914; NP_665915
	Wikidata
View/Edit Human	View/Edit Mouse

PORCN (porcupine homolog – Drosophila) is a human gene.^[5]^[6] The protein is homologous to other membrane-bound O-acyltransferases.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102312 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031169 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (July 2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". European Journal of Biochemistry. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
^ Caricasole A, Ferraro T, Rimland JM, Terstappen GC (April 2002). "Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine". Gene. 288 (1–2): 147–57. doi:10.1016/S0378-1119(02)00467-5. PMID 12034504.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031169 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10866835-5] Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (July 2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". European Journal of Biochemistry. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.

[pmid12034504-6] Caricasole A, Ferraro T, Rimland JM, Terstappen GC (April 2002). "Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine". Gene. 288 (1–2): 147–57. doi:10.1016/S0378-1119(02)00467-5. PMID 12034504.

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