PPIB

PPIB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CYN, 3ICH, 3ICI
Identifiers
Aliases	PPIB, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP, peptidylprolyl isomerase B, B
External IDs	OMIM: 123841; MGI: 97750; HomoloGene: 726; GeneCards: PPIB; OMA:PPIB - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,163,134 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,973,905 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; corpus epididymis; ; caput epididymis; ; right lobe of thyroid gland; ; anterior pituitary; ; seminal vesicula; ; left lobe of thyroid gland; ; parotid gland; ; tail of epididymis; ; pericardium;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; vestibular sensory epithelium; ; fossa; ; vas deferens; ; condyle; ; endothelial cell of lymphatic vessel; ; Paneth cell; ; utricle; ; efferent ductule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	collagen binding; unfolded protein binding; protein-containing complex binding; isomerase activity; protein binding; RNA polymerase binding; RNA binding; peptidyl-prolyl cis-trans isomerase activity; cyclosporin A binding;
Cellular component	protein-containing complex; endoplasmic reticulum lumen; membrane; focal adhesion; melanosome; smooth endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular exosome; nucleus;
Biological process	protein stabilization; regulation of post-translational protein modification; protein peptidyl-prolyl isomerization; positive regulation by host of viral genome replication; positive regulation by host of viral process; protein folding; positive regulation of multicellular organism growth; bone development; chaperone-mediated protein folding; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	5479
	19035
	ENSG00000166794
	ENSMUSG00000032383
	P23284
	P24369
	NM_000942
	NM_011149
	NP_000933
	NP_035279
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase B is an enzyme that is encoded by the PPIB gene.^[5] As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate protein folding of type I collagen.^[6]^[7] Generally, PPIases are found in all eubacteria and eukaryotes, as well as in a few archaebacteria, and thus are highly conserved.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166794 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032383 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence". Proc Natl Acad Sci U S A. 88 (5): 1903–7. Bibcode:1991PNAS...88.1903P. doi:10.1073/pnas.88.5.1903. PMC 51134. PMID 2000394.
^ Kazui T, Inoue N, Yamada O, Komatsu S (Jan 1992). "Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery. 53 (1): 109–14. doi:10.1016/0003-4975(92)90767-x. PMID 1530810.
^ Hoffmann H, Schiene-Fischer C (Jul 2014). "Functional aspects of extracellular cyclophilins". Biological Chemistry. 395 (7–8): 721–35. doi:10.1515/hsz-2014-0125. PMID 24713575. S2CID 32395688.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166794 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032383 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2000394-5] Price ER, Zydowsky LD, Jin MJ, Baker CH, McKeon FD, Walsh CT (Apr 1991). "Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence". Proc Natl Acad Sci U S A. 88 (5): 1903–7. Bibcode:1991PNAS...88.1903P. doi:10.1073/pnas.88.5.1903. PMC 51134. PMID 2000394.

[pmid1530810-6] Kazui T, Inoue N, Yamada O, Komatsu S (Jan 1992). "Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery. 53 (1): 109–14. doi:10.1016/0003-4975(92)90767-x. PMID 1530810.

[pmid24713575-7] Hoffmann H, Schiene-Fischer C (Jul 2014). "Functional aspects of extracellular cyclophilins". Biological Chemistry. 395 (7–8): 721–35. doi:10.1515/hsz-2014-0125. PMID 24713575. S2CID 32395688.

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