PPP1R12A

PPP1R12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KJY, 2MXR, 5HUZ
Identifiers
Aliases	PPP1R12A, M130, MBS, MYPT1, protein phosphatase 1 regulatory subunit 12A, GUBS
External IDs	OMIM: 602021; MGI: 1309528; HomoloGene: 1855; GeneCards: PPP1R12A; OMA:PPP1R12A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	79,935,460 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	108,120,336 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; saphenous vein; ; tail of epididymis; ; epithelium of colon; ; popliteal artery; ; tibial arteries; ; urethra; ; right coronary artery; ; vena cava;
	Top expressed in
	ascending aorta; ; aortic valve; ; conjunctival fornix; ; zygote; ; secondary oocyte; ; iris; ; otolith organ; ; primary oocyte; ; utricle; ; hand;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; 14-3-3 protein binding; signal transducer activity; protein binding; protein kinase binding; phosphatase regulator activity;
Cellular component	centrosome; focal adhesion; nucleoplasm; Z discdkac; PTW/PP1 phosphatase complex; actin cytoskeleton; contractile fiber; A band; kinetochore; cytoplasm; cytosol; cytoskeleton;
Biological process	regulation of nucleocytoplasmic transport; positive regulation of myosin-light-chain-phosphatase activity; negative regulation of catalytic activity; regulation of cell adhesion; G2/M transition of mitotic cell cycle; regulation of myosin-light-chain-phosphatase activity; regulation of establishment of endothelial barrier; positive regulation of transcription by RNA polymerase II; signal transduction; protein dephosphorylation; mitotic cell cycle; centrosome cycle;
	Sources:Amigo / QuickGO
Orthologs
	4659
	17931
	ENSG00000058272
	ENSMUSG00000019907
	O14974
	Q9DBR7
	NM_001143885; NM_001143886; NM_001244990; NM_001244992; NM_002480
	NM_027892; NM_001368736; NM_001368737
	NP_001137357; NP_001137358; NP_001231919; NP_001231921; NP_002471
	NP_082168; NP_001355665; NP_001355666
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 12A is an enzyme that in humans is encoded by the PPP1R12A gene.^[5]^[6]

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle ^[7] and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000058272 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019907 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahashi N, Ito M, Tanaka J, Nakano T, Kaibuchi K, Odai H, Takemura K (Nov 1997). "Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21". Genomics. 44 (1): 150–2. doi:10.1006/geno.1997.4859. PMID 9286714.
^ ^a ^b "Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A".
^ Michael P. Walsh; et al. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). Archived from the original (PDF) on 2011-07-13.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000058272 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019907 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9286714-5] Takahashi N, Ito M, Tanaka J, Nakano T, Kaibuchi K, Odai H, Takemura K (Nov 1997). "Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21". Genomics. 44 (1): 150–2. doi:10.1006/geno.1997.4859. PMID 9286714.

[entrez-6] "Entrez Gene: PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A".

[7] Michael P. Walsh; et al. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). Archived from the original (PDF) on 2011-07-13.

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