PPP1R1B

PPP1R1B
Identifiers
Aliases	PPP1R1B, DARPP-32, DARPP32, protein phosphatase 1 regulatory inhibitor subunit 1B
External IDs	OMIM: 604399; MGI: 94860; HomoloGene: 12972; GeneCards: PPP1R1B; OMA:PPP1R1B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,636,626 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,248,622 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; nucleus accumbens; ; external globus pallidus; ; mucosa of ileum; ; mucosa of transverse colon; ; rectum; ; right frontal lobe; ; amygdala; ; Brodmann area 9;
	Top expressed in
	olfactory tubercle; ; superior frontal gyrus; ; globus pallidus; ; nucleus accumbens; ; parotid gland; ; primary visual cortex; ; piriform cortex; ; Epithelium of choroid plexus; ; cerebellar cortex; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine phosphatase inhibitor activity; protein kinase inhibitor activity; protein binding; cAMP-dependent protein kinase inhibitor activity; protein phosphatase regulator activity; protein phosphatase inhibitor activity; D1 dopamine receptor binding; D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding; D5 dopamine receptor binding;
Cellular component	cytoplasm; soma; nucleus; cytosol; dendritic spine neck; dendritic spine head; postsynapse; glutamatergic synapse;
Biological process	visual learning; intracellular signal transduction; response to amphetamine; transcription, DNA-templated; negative regulation of female receptivity; signal transduction; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of phosphoprotein phosphatase activity; locomotory behavior; response to morphine; behavioral response to cocaine; response to cocaine; memory; response to nicotine;
	Sources:Amigo / QuickGO
Orthologs
	84152
	19049
	ENSG00000131771
	ENSMUSG00000061718
	Q9UD71
	Q60829
	NM_001242464; NM_032192; NM_181505
	NM_144828; NM_001313970
	NP_001229393; NP_115568; NP_852606; NP_115568.2
	NP_001300899; NP_659077
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131771 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061718 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)".
^ Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (March 1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". The Journal of Neuroscience. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131771 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061718 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)".

[pmid8120638-6] Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (March 1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". The Journal of Neuroscience. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.

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