PPP2CA

PPP2CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IAE, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 3C5W, 3DW8, 3FGA, 3K7V, 3K7W, 3P71, 4I5L, 4I5N, 4IYP, 4LAC
Identifiers
Aliases	PPP2CA, PP2Ac, PP2CA, PP2Calpha, RP-C, protein phosphatase 2 catalytic subunit alpha, NEDLBA
External IDs	OMIM: 176915; MGI: 1321159; HomoloGene: 37660; GeneCards: PPP2CA; OMA:PPP2CA - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,226,073 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	52,018,605 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; Skeletal muscle tissue of rectus abdominis; ; postcentral gyrus; ; prefrontal cortex; ; Pars compacta; ; pons; ; right ventricle;
	Top expressed in
	medial ganglionic eminence; ; molar; ; nucleus accumbens; ; substantia nigra; ; endocardial cushion; ; barrel cortex; ; atrioventricular valve; ; dorsal striatum; ; abdominal wall; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; GABA receptor binding; metal ion binding; protein C-terminus binding; protein binding; hydrolase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; tau protein binding;
Cellular component	cytoplasm; cytosol; spindle pole; membrane; microtubule cytoskeleton; plasma membrane; protein phosphatase type 2A complex; chromosome; mitochondrion; chromosome, centromeric region; cytoskeleton; extracellular exosome; nucleus; membrane raft; synapse;
Biological process	apoptotic process; regulation of transcription, DNA-templated; ceramide metabolic process; regulation of DNA replication; protein dephosphorylation; response to organic substance; positive regulation of protein serine/threonine kinase activity; regulation of Wnt signaling pathway; regulation of cell adhesion; meiosis; negative regulation of cell growth; RNA splicing; regulation of cell differentiation; regulation of growth; mitotic nuclear membrane reassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mesoderm development; second-messenger-mediated signaling; negative regulation of epithelial to mesenchymal transition; negative regulation of tyrosine phosphorylation of STAT protein; regulation of protein phosphorylation; response to lead ion; peptidyl-threonine dephosphorylation; peptidyl-serine dephosphorylation; regulation of microtubule binding; positive regulation of microtubule binding;
	Sources:Amigo / QuickGO
Orthologs
	5515
	19052
	ENSG00000113575
	ENSMUSG00000020349
	P67775
	P63330
	NM_002715; NM_001355019
	NM_019411
	NP_002706; NP_001341948
	NP_062284
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that (in humans) is encoded by the PPP2CA gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113575 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020349 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics. 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113575 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020349 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8383590-5] Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics. 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.

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