PPP2CB

PPP2CB
Identifiers
Aliases	PPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta
External IDs	OMIM: 176916; MGI: 1321161; HomoloGene: 37889; GeneCards: PPP2CB; OMA:PPP2CB - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	30,814,314 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	34,109,469 bp
RNA expression pattern
	Top expressed in
	pons; ; superior vestibular nucleus; ; subthalamic nucleus; ; lateral nuclear group of thalamus; ; optic nerve; ; postcentral gyrus; ; external globus pallidus; ; bronchial epithelial cell; ; jejunal mucosa; ; pars reticulata;
	Top expressed in
	spermatid; ; molar; ; granulocyte; ; spermatocyte; ; left colon; ; seminiferous tubule; ; ventricular zone; ; medial ganglionic eminence; ; parotid gland; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; metal ion binding; protein binding; hydrolase activity; protein serine/threonine phosphatase activity; protein C-terminus binding; tau protein binding;
Cellular component	cytoplasm; cytosol; spindle pole; protein phosphatase type 2A complex; chromosome; chromosome, centromeric region; extracellular exosome; cytoskeleton; nucleus;
Biological process	response to antibiotic; response to endoplasmic reticulum stress; apoptotic mitochondrial changes; regulation of gene expression; response to hydrogen peroxide; proteasome-mediated ubiquitin-dependent protein catabolic process; protein dephosphorylation; negative regulation of Ras protein signal transduction; response to lead ion; peptidyl-threonine dephosphorylation; peptidyl-serine dephosphorylation; positive regulation of microtubule binding;
	Sources:Amigo / QuickGO
Orthologs
	5516
	19053
	ENSG00000104695
	ENSMUSG00000009630
	P62714
	P62715
	NM_004156; NM_001009552
	NM_017374
	NP_001009552
	NP_059070
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104695 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009630 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics. 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104695 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009630 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8383590-5] Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics. 63 (1): 35–41. doi:10.1159/000133497. PMID 8383590.

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