PRDM1

PRDM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DAL
Identifiers
Aliases	PRDM1, BLIMP1, PRDI-BF1, PR domain 1, PR/SET domain 1
External IDs	OMIM: 603423; MGI: 99655; HomoloGene: 925; GeneCards: PRDM1; OMA:PRDM1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	106,109,939 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	44,404,497 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; oral cavity; ; mucosa of pharynx; ; stromal cell of endometrium; ; rectum; ; skin of thigh; ; blood; ; vagina; ; bone marrow cells; ; superficial temporal artery;
	Top expressed in
	gastrula; ; decidua; ; otic placode; ; zygote; ; otic vesicle; ; migratory enteric neural crest cell; ; lip; ; skin of back; ; esophagus; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; promoter-specific chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin DNA binding;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	germ cell development; trophoblast giant cell differentiation; cardiac septum development; cell fate commitment; heart valve development; regulation of transcription, DNA-templated; ventricular septum development; intestinal epithelial cell development; positive regulation of B cell differentiation; embryonic placenta development; in utero embryonic development; negative regulation of transcription by RNA polymerase II; post-embryonic development; coronary vasculature development; negative regulation of gene expression; morphogenesis of a branching structure; transcription, DNA-templated; negative regulation of lipopolysaccharide-mediated signaling pathway; aorta development; methylation; positive regulation of gene expression; maternal placenta development; regulation of cell population proliferation; artery morphogenesis; eye photoreceptor cell development; sebum secreting cell proliferation; negative regulation of B cell proliferation; adaptive immune response; immune system process; regulation of natural killer cell differentiation; regulation of extrathymic T cell differentiation; innate immune response; regulation of NK T cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	639
	12142
	ENSG00000057657
	ENSMUSG00000038151
	O75626
	Q60636
	NM_001198; NM_182907
	NM_007548
	NP_001189; NP_878911
NP_031574; NP_001392858; NP_001392859; NP_001392860; NP_001392861;
	NP_001392862; NP_001392863; NP_001392864; NP_001392865
	Wikidata
View/Edit Human	View/Edit Mouse

PR domain zinc finger protein 1, or B lymphocyte-induced maturation protein-1 (BLIMP-1), is a protein in humans encoded by the gene PRDM1 located on chromosome 6q21.^[5] BLIMP-1 is considered a 'master regulator' of hematopoietic stem cells, and plays a critical role in the development of plasma B cells, T cells, dendritic cells (DCs), macrophages, and osteoclasts. Pattern Recognition Receptors (PRRs) can activate BLIMP-1, both as a direct target and through downstream activation.^[6]^[7]^[8] BLIMP-1 is a transcription factor that triggers expression of many downstream signaling cascades.^[6]^[9]^[10]^[11] As a fine-tuned and contextual rheostat of the immune system, BLIMP-1 up- or down-regulates immune responses depending on the precise scenarios.^[6]^[10]^[12] BLIMP-1 is highly expressed in exhausted T-cells – clones of dysfunctional T-cells with diminished functions due to chronic immune response against cancer, viral infections, or organ transplant.^[7]^[8]^[13]^[14]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000057657 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038151 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Boi M, Zucca E, Inghirami G, Bertoni F (May 2015). "PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas". Leukemia & Lymphoma. 56 (5): 1223–1228. doi:10.3109/10428194.2014.953155. PMID 25115512. S2CID 7518347.
^ ^a ^b ^c Ulmert I, Henriques-Oliveira L, Pereira CF, Lahl K (December 2020). "Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease". Immunology. 161 (4): 303–313. doi:10.1111/imm.13249. PMC 7692253. PMID 32799350.
^ ^a ^b Wells AD, Li XC, Strom TB, Turka LA (May 2001). "The role of peripheral T-cell deletion in transplantation tolerance". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356 (1409): 617–623. doi:10.1098/rstb.2001.0845. PMC 1088449. PMID 11375065.
^ ^a ^b Crawford A, Angelosanto JM, Kao C, Doering TA, Odorizzi PM, Barnett BE, Wherry EJ (February 2014). "Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection". Immunity. 40 (2): 289–302. doi:10.1016/j.immuni.2014.01.005. PMC 3990591. PMID 24530057.
^ Kim SJ (December 2015). "Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases". Immunologic Research. 63 (1–3): 113–120. doi:10.1007/s12026-015-8694-5. PMC 4651792. PMID 26376898.
^ ^a ^b Turner, C. Alexander; Mack, David H.; Davis, Mark M. (1994-04-22). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells". Cell. 77 (2): 297–306. doi:10.1016/0092-8674(94)90321-2. ISSN 0092-8674. PMID 8168136. S2CID 46200658.
^ Sciammas R, Davis MM (May 2004). "Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation". Journal of Immunology. 172 (9): 5427–5440. doi:10.4049/jimmunol.172.9.5427. PMID 15100284.
^ Tellier J, Nutt SL (January 2019). "Plasma cells: The programming of an antibody-secreting machine". European Journal of Immunology. 49 (1): 30–37. doi:10.1002/eji.201847517. hdl:11343/284565. PMID 30273443. S2CID 52901472.
^ Fu SH, Yeh LT, Chu CC, Yen BL, Sytwu HK (July 2017). "New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function". Journal of Biomedical Science. 24 (1): 49. doi:10.1186/s12929-017-0354-8. PMC 5520377. PMID 28732506.
^ Collier JL, Weiss SA, Pauken KE, Sen DR, Sharpe AH (July 2021). "Not-so-opposite ends of the spectrum: CD8⁺ T cell dysfunction across chronic infection, cancer and autoimmunity". Nature Immunology. 22 (7): 809–819. doi:10.1038/s41590-021-00949-7. PMC 9197228. PMID 34140679.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000057657 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Boi M, Zucca E, Inghirami G, Bertoni F (May 2015). "PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas". Leukemia & Lymphoma. 56 (5): 1223–1228. doi:10.3109/10428194.2014.953155. PMID 25115512. S2CID 7518347.

[:1-6] Ulmert I, Henriques-Oliveira L, Pereira CF, Lahl K (December 2020). "Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease". Immunology. 161 (4): 303–313. doi:10.1111/imm.13249. PMC 7692253. PMID 32799350.

[:6-7] Wells AD, Li XC, Strom TB, Turka LA (May 2001). "The role of peripheral T-cell deletion in transplantation tolerance". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 356 (1409): 617–623. doi:10.1098/rstb.2001.0845. PMC 1088449. PMID 11375065.

[:7-8] Crawford A, Angelosanto JM, Kao C, Doering TA, Odorizzi PM, Barnett BE, Wherry EJ (February 2014). "Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection". Immunity. 40 (2): 289–302. doi:10.1016/j.immuni.2014.01.005. PMC 3990591. PMID 24530057.

[:3-9] Kim SJ (December 2015). "Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases". Immunologic Research. 63 (1–3): 113–120. doi:10.1007/s12026-015-8694-5. PMC 4651792. PMID 26376898.

[:2-10] Turner, C. Alexander; Mack, David H.; Davis, Mark M. (1994-04-22). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells". Cell. 77 (2): 297–306. doi:10.1016/0092-8674(94)90321-2. ISSN 0092-8674. PMID 8168136. S2CID 46200658.

[pmid15100284-11] Sciammas R, Davis MM (May 2004). "Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation". Journal of Immunology. 172 (9): 5427–5440. doi:10.4049/jimmunol.172.9.5427. PMID 15100284.

[:4-12] Tellier J, Nutt SL (January 2019). "Plasma cells: The programming of an antibody-secreting machine". European Journal of Immunology. 49 (1): 30–37. doi:10.1002/eji.201847517. hdl:11343/284565. PMID 30273443. S2CID 52901472.

[:5-13] Fu SH, Yeh LT, Chu CC, Yen BL, Sytwu HK (July 2017). "New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function". Journal of Biomedical Science. 24 (1): 49. doi:10.1186/s12929-017-0354-8. PMC 5520377. PMID 28732506.

[:8-14] Collier JL, Weiss SA, Pauken KE, Sen DR, Sharpe AH (July 2021). "Not-so-opposite ends of the spectrum: CD8⁺ T cell dysfunction across chronic infection, cancer and autoimmunity". Nature Immunology. 22 (7): 809–819. doi:10.1038/s41590-021-00949-7. PMC 9197228. PMID 34140679.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]