PRDX5

PRDX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4O, 1HD2, 1OC3, 1URM, 2VL2, 2VL3, 2VL9, 3MNG, 4K7I, 4K7N, 4K7O, 4MMM
Identifiers
Aliases	PRDX5, ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, prx-V, SBBI10, peroxiredoxin 5
External IDs	OMIM: 606583; MGI: 1859821; HomoloGene: 8076; GeneCards: PRDX5; OMA:PRDX5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,318,121 bp[1] End 64,321,811 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 5.08 cM Start 6,884,065 bp[2] End 6,887,474 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell epithelium of nasopharynx palpebral conjunctiva right uterine tube mucosa of transverse colon apex of heart olfactory zone of nasal mucosa right adrenal gland right adrenal cortex right lobe of thyroid gland Top expressed in granulocyte right kidney human kidney dentate gyrus of hippocampal formation granule cell choroid plexus of fourth ventricle medial vestibular nucleus vestibular membrane of cochlear duct lip deep cerebellar nuclei transitional epithelium of urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function peroxynitrite reductase activity protein dimerization activity peroxidase activity RNA polymerase III transcription regulatory region sequence-specific DNA binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process antioxidant activity peroxiredoxin activity oxidoreductase activity signaling receptor binding thioredoxin peroxidase activity protein binding Cellular component cytoplasm cytosol intracellular membrane-bounded organelle peroxisome mitochondrial matrix mitochondrion perinuclear region of cytoplasm extracellular exosome cytoplasmic vesicle nucleus extracellular space peroxisomal matrix Biological process positive regulation of collagen biosynthetic process NADPH oxidation negative regulation of apoptotic process response to oxidative stress cellular response to reactive oxygen species regulation of apoptosis involved in tissue homeostasis negative regulation of transcription by RNA polymerase III negative regulation of oxidoreductase activity hydrogen peroxide catabolic process reactive nitrogen species metabolic process inflammatory response negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular oxidant detoxification cell redox homeostasis apoptotic process cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25824 54683 Ensembl ENSG00000126432 ENSMUSG00000024953 UniProt P30044 P99029 RefSeq (mRNA) NM_012094 NM_181651 NM_181652 NM_001358511 NM_001358516 NM_012021 NM_001358444 RefSeq (protein) NP_036226 NP_857634 NP_857635 NP_001345440 NP_001345445 NP_036151 NP_001345373 Location (UCSC) Chr 11: 64.32 – 64.32 Mb Chr 19: 6.88 – 6.89 Mb PubMed search [3] [4]
Wikidata
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Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11.^[5]

This gene encodes a member of the six-member peroxiredoxin family of antioxidant enzymes. Like the other five members, PRDX5 is widely expressed in tissues but differs by its large subcellular distribution.^[6] In human cells, it has been shown that PRDX5 can be localized to mitochondria, peroxisomes, the cytosol, and the nucleus.^[7] Human PRDX5 is identified by virtue of the sequence homologies to yeast peroxisomal antioxidant enzyme PMP20.^[6][8]

Biochemically, PRDX5 is a peroxidase that can use cytosolic or mitochondrial thioredoxins to reduce alkyl hydroperoxides or peroxynitrite with high rate constants in the 10⁶ to 10⁷ M⁻¹s⁻¹ range, whereas its reaction with hydrogen peroxide is more modest, in the 10⁵ M⁻¹s⁻¹ range.^[7] So far, PRDX5 has been shown to be a cytoprotective antioxidant enzyme that inhibits endogenous or exogenous peroxide accumulation.^[7]