PRKACA

PRKACA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GU8, 3AGL, 3AGM, 3AMA, 3AMB, 3L9L, 3L9M, 3L9N, 3MVJ, 3NX8, 3OOG, 3OVV, 3OWP, 3OXT, 3P0M, 3POO, 3VQH, 4AE6, 4AE9, 4WB5, 4WB6, 4WB7, 4WB8, 5IZJ, 4UJB, 4UJA, 4UJ2, 4UJ1, 4UJ9
Identifiers
Aliases	PRKACA, PKACA, PPNAD4, protein kinase cAMP-activated catalytic subunit alpha, CAFD1
External IDs	OMIM: 601639; MGI: 97592; HomoloGene: 121574; GeneCards: PRKACA; OMA:PRKACA - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,091,688 bp[1] End 14,118,084 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,699,622 bp[2] End 84,723,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle apex of heart left ventricle right auricle skeletal muscle tissue muscle of thigh left adrenal gland left adrenal cortex right adrenal cortex smooth muscle tissue Top expressed in dentate gyrus of hippocampal formation granule cell dorsomedial hypothalamic nucleus entorhinal cortex perirhinal cortex superior frontal gyrus primary visual cortex brown adipose tissue muscle of thigh medulla oblongata central gray substance of midbrain More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity ATP binding protein kinase activity transferase activity protein binding protein serine/threonine/tyrosine kinase activity protein kinase binding nucleotide binding ubiquitin protein ligase binding cAMP-dependent protein kinase activity magnesium ion binding protein serine/threonine kinase activity protein domain specific binding manganese ion binding protein kinase A regulatory subunit binding Cellular component calcium channel complex membrane mitochondrion nucleus centrosome cell projection nuclear speck cilium motile cilium extracellular exosome plasma membrane nucleoplasm nucleotide-activated protein kinase complex sperm midpiece plasma membrane raft acrosomal vesicle cytoplasm cytosol cytoplasmic vesicle intercellular bridge perinuclear region of cytoplasm neuromuscular junction sperm flagellum dendritic spine ciliary base cAMP-dependent protein kinase complex axoneme Biological process activation of protein kinase A activity regulation of bicellular tight junction assembly cellular response to epinephrine stimulus protein phosphorylation regulation of osteoblast differentiation G2/M transition of mitotic cell cycle cellular response to glucose stimulus regulation of cytosolic calcium ion concentration stimulatory C-type lectin receptor signaling pathway phosphorylation regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion cellular response to glucagon stimulus mRNA processing regulation of heart rate calcium-mediated signaling using intracellular calcium source regulation of proteasomal protein catabolic process regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac conduction cell communication by electrical coupling involved in cardiac conduction blood coagulation renal water homeostasis regulation of cardiac muscle contraction regulation of protein binding regulation of macroautophagy cellular response to heat ciliary basal body-plasma membrane docking mesoderm formation neural tube closure peptidyl-threonine phosphorylation protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation modulation of chemical synaptic transmission regulation of protein processing cellular response to parathyroid hormone stimulus negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning peptidyl-serine phosphorylation high-density lipoprotein particle assembly regulation of G2/M transition of mitotic cell cycle protein kinase A signaling cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5566 18747 Ensembl ENSG00000072062 ENSG00000288516 ENSMUSG00000005469 UniProt P17612 P05132 RefSeq (mRNA) NM_207518 NM_001304349 NM_002730 NM_001277898 NM_008854 RefSeq (protein) NP_001291278 NP_002721 NP_997401 NP_001264827 NP_032880 Location (UCSC) Chr 19: 14.09 – 14.12 Mb Chr 8: 84.7 – 84.72 Mb PubMed search [3] [4]
Wikidata
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The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene.^[5] This enzyme is responsible for phosphorylating other proteins and substrates, changing their activity. Protein kinase A catalytic subunit (PKA Cα) is a member of the AGC kinase family (protein kinases A, G, and C), and contributes to the control of cellular processes that include glucose metabolism, cell division, and contextual memory.^[6][7][8] PKA Cα is part of a larger protein complex that is responsible for controlling when and where proteins are phosphorylated. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.