PRKG1

PRKG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZXA, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK, 4R4L, 4R4M, 4Z07
Identifiers
Aliases	PRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
External IDs	OMIM: 176894; MGI: 108174; HomoloGene: 55964; GeneCards: PRKG1; OMA:PRKG1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	52,298,423 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	31,742,433 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Descending thoracic aorta; ; ascending aorta; ; Skeletal muscle tissue of rectus abdominis; ; right coronary artery; ; popliteal artery; ; urethra; ; tibial arteries;
	Top expressed in
	spermatid; ; lumbar spinal ganglion; ; epithelium of lens; ; trigeminal ganglion; ; soleus muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; temporal muscle; ; intercostal muscle; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium channel regulator activity; cGMP binding; kinase activity; protein binding; catalytic activity; ATP binding; protein serine/threonine kinase activity; cGMP-dependent protein kinase activity; identical protein binding; protein kinase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; plasma membrane;
Biological process	negative regulation of smooth muscle contraction; phosphorylation; regulation of GTPase activity; dendrite development; neuron migration; negative regulation of platelet aggregation; cGMP-mediated signaling; relaxation of vascular associated smooth muscle; forebrain development; metabolism; actin cytoskeleton organization; signal transduction; protein phosphorylation; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration;
	Sources:Amigo / QuickGO
Orthologs
	5592
	19091
	ENSG00000185532
	ENSMUSG00000052920
	Q13976
	P0C605
	NM_001098512; NM_006258; NM_001374781; NM_001374782
	NM_001013833; NM_011160
	NP_001091982; NP_006249; NP_001361710; NP_001361711
	NP_001013855; NP_035290
	Wikidata
View/Edit Human	View/Edit Mouse

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185532 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052920 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381. S2CID 83233954.
^ Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
^ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185532 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052920 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2792381-5] Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381. S2CID 83233954.

[pmid1544322-6] Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.

[entrez-7] "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".

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