PRMT6

PRMT6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HC4, 4QPP, 4QQK, 4Y2H, 4Y30, 5EGS, 5E8R, 5HZM
Identifiers
Aliases	PRMT6, HRMT1L6, protein arginine methyltransferase 6
External IDs	OMIM: 608274; MGI: 2139971; HomoloGene: 10024; GeneCards: PRMT6; OMA:PRMT6 - orthologs
EC number	2.1.1.321
Gene location (Human)
Chr.	Chromosome 1 (human)
End	107,067,636 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	110,158,314 bp
RNA expression pattern
	Top expressed in
	gonad; ; islet of Langerhans; ; palpebral conjunctiva; ; right adrenal cortex; ; mucosa of sigmoid colon; ; metanephros; ; testicle; ; left adrenal gland; ; left adrenal cortex; ; prefrontal cortex;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; spermatocyte; ; endocardial cushion; ; epiblast; ; embryo; ; primitive streak; ; yolk sac; ; tail of embryo; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; histone methyltransferase activity (H4-R3 specific); histone binding; protein-arginine omega-N asymmetric methyltransferase activity; chromatin binding; histone methyltransferase activity (H2A-R3 specific); histone methyltransferase activity (H3-R2 specific); protein binding; protein-arginine N-methyltransferase activity; histone-arginine N-methyltransferase activity;
Cellular component	nucleoplasm; nucleus; nucleolus; cytosol;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; cellular senescence; methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; histone methylation; viral process; negative regulation of transcription, DNA-templated; DNA repair; base-excision repair; protein methylation; histone H4-R3 methylation; regulation of megakaryocyte differentiation; chromatin organization; histone H3-R2 methylation; peptidyl-arginine N-methylation; negative regulation of histone H3-K4 methylation; regulation of signal transduction by p53 class mediator; histone arginine methylation;
	Sources:Amigo / QuickGO
Orthologs
	55170
	99890
	ENSG00000198890
	ENSMUSG00000049300
	Q96LA8
	Q6NZB1
	NM_018137
	NM_178891
	NP_060607
	NP_849222
	Wikidata
View/Edit Human	View/Edit Mouse

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.^[5]^[6]

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198890 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049300 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT (Jan 2002). "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity". J Biol Chem. 277 (5): 3537–43. doi:10.1074/jbc.M108786200. PMID 11724789.
^ ^a ^b "Entrez Gene: PRMT6 protein arginine methyltransferase 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198890 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049300 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11724789-5] Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT (Jan 2002). "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity". J Biol Chem. 277 (5): 3537–43. doi:10.1074/jbc.M108786200. PMID 11724789.

[entrez-6] "Entrez Gene: PRMT6 protein arginine methyltransferase 6".

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