PSMB1

PSMB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R3O, 4R67, 5A0Q
Identifiers
Aliases	PSMB1, HC5, PMSB1, PSC5, proteasome subunit beta 1, proteasome 20S subunit beta 1
External IDs	OMIM: 602017; MGI: 104884; HomoloGene: 2087; GeneCards: PSMB1; OMA:PSMB1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 170,535,120 bp[1] End 170,553,307 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 15,695,283 bp[2] End 15,720,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium parietal pleura visceral pleura epithelium of nasopharynx retinal pigment epithelium amniotic fluid middle temporal gyrus tibia seminal vesicula germinal epithelium Top expressed in medial ganglionic eminence facial motor nucleus transitional epithelium of urinary bladder efferent ductule anterior horn of spinal cord endocardial cushion abdominal wall right lung lobe otic placode maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endopeptidase activity peptidase activity protein binding threonine-type endopeptidase activity hydrolase activity Cellular component cytoplasm cytosol nucleoplasm proteasome complex extracellular exosome nucleus proteasome core complex extracellular region secretory granule lumen ficolin-1-rich granule lumen proteasome core complex, beta-subunit complex Biological process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade proteolysis Fc-epsilon receptor signaling pathway NIK/NF-kappaB signaling anaphase-promoting complex-dependent catabolic process proteolysis involved in cellular protein catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process viral process Wnt signaling pathway, planar cell polarity pathway negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process neutrophil degranulation transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5689 19170 Ensembl ENSG00000008018 ENSG00000281184 ENSMUSG00000014769 UniProt P20618 O09061 RefSeq (mRNA) NM_002793 NM_011185 RefSeq (protein) NP_002784 NP_035315 Location (UCSC) Chr 6: 170.54 – 170.55 Mb Chr 17: 15.7 – 15.72 Mb PubMed search [3] [4]
Wikidata
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Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB1 gene.^[5] This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-1, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.