PSMB10

PSMB10
Identifiers
Aliases	PSMB10, LMP10, MECL1, beta2i, proteasome subunit beta 10, proteasome 20S subunit beta 10, PRAAS5
External IDs	OMIM: 176847; MGI: 1096380; HomoloGene: 20616; GeneCards: PSMB10; OMA:PSMB10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,934,506 bp[1] End 67,936,864 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.06 cM Start 106,662,367 bp[2] End 106,665,076 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen mucosa of transverse colon duodenum putamen appendix substantia nigra apex of heart Top expressed in duodenum Ileal epithelium jejunum thymus crypt of lieberkuhn of small intestine embryo colon spleen dentate gyrus of hippocampal formation granule cell mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function endopeptidase activity peptidase activity protein binding threonine-type endopeptidase activity hydrolase activity Cellular component cytoplasm cytosol nucleoplasm proteasome complex nucleus proteasome core complex spermatoproteasome complex proteasome core complex, beta-subunit complex Biological process proteolysis humoral immune response proteolysis involved in cellular protein catabolic process viral process protein deubiquitination immune system process post-translational protein modification cell morphogenesis proteasomal protein catabolic process proteasomal ubiquitin-independent protein catabolic process T cell proliferation proteasome-mediated ubiquitin-dependent protein catabolic process MAPK cascade protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of cellular amino acid metabolic process negative regulation of G2/M transition of mitotic cell cycle anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway regulation of mRNA stability T cell receptor signaling pathway transmembrane transport Wnt signaling pathway, planar cell polarity pathway regulation of transcription from RNA polymerase II promoter in response to hypoxia interleukin-1-mediated signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of mitotic cell cycle phase transition regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5699 19171 Ensembl ENSG00000205220 ENSMUSG00000031897 UniProt P40306 O35955 RefSeq (mRNA) NM_002801 NM_013640 RefSeq (protein) NP_002792 NP_038668 Location (UCSC) Chr 16: 67.93 – 67.94 Mb Chr 8: 106.66 – 106.67 Mb PubMed search [3] [4]
Wikidata
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Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene.^[5]

This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and formed by replacing constitutive beta subunits with inducible beta subunits which possess specific cleavage properties that aid in the release of peptides necessary for MHC class I antigen presentation.^[6] The immunoproteasome appears to have a pivotal role in modulating NFκB signaling.^[7]