PSMB9

PSMB9
Identifiers
Aliases	PSMB9, LMP2, PSMB6i, RING12, beta1i, proteasome subunit beta 9, PRAAS3, proteasome 20S subunit beta 9
External IDs	OMIM: 177045; MGI: 1346526; HomoloGene: 2094; GeneCards: PSMB9; OMA:PSMB9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,859,851 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,406,738 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; lymph node; ; appendix; ; blood; ; spleen; ; duodenum; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; right lung;
	Top expressed in
	spleen; ; thymus; ; mesenteric lymph nodes; ; granulocyte; ; duodenum; ; jejunum; ; mucous cell of stomach; ; intestinal villus; ; blood; ; lactiferous gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; peptidase activity; protein binding; threonine-type endopeptidase activity; hydrolase activity;
Cellular component	spermatoproteasome complex; nucleoplasm; proteasome complex; extracellular exosome; nucleus; proteasome core complex; cytoplasm; cytosol; proteasome core complex, beta-subunit complex;
Biological process	regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of mRNA stability; regulation of cysteine-type endopeptidase activity; positive regulation of canonical Wnt signaling pathway; immune system process; protein polyubiquitination; stimulatory C-type lectin receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; MAPK cascade; proteolysis; Fc-epsilon receptor signaling pathway; NIK/NF-kappaB signaling; anaphase-promoting complex-dependent catabolic process; proteolysis involved in cellular protein catabolic process; T cell receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; viral process; Wnt signaling pathway, planar cell polarity pathway; negative regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; transmembrane transport; regulation of transcription from RNA polymerase II promoter in response to hypoxia; post-translational protein modification; regulation of hematopoietic stem cell differentiation; proteasomal protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; interleukin-1-mediated signaling pathway; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	5698
	16912
ENSG00000240118; ENSG00000243067; ENSG00000240065; ENSG00000240508; ENSG00000242711;
	ENSG00000243594; ENSG00000243958; ENSG00000239836
	ENSMUSG00000096727
	P28065
	P28076
	NM_002800; NM_148954
	NM_013585
	NP_002791
	NP_038613
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasome subunit beta type-9 as known as 20S proteasome subunit beta-1i is a protein that in humans is encoded by the PSMB9 gene.^[5]^[6]^[7]

This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "Trypsin-like" activity and is capable of cleaving after basic residues of peptide.^[8] The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. The constitutive subunit beta1, beta2, and beta 5 (systematic nomenclature) can be replaced by their inducible counterparts beta1i, 2i, and 5i when cells are under the treatment of interferon-γ. The resulting proteasome complex becomes the so-called immunoproteasome. An essential function of the modified proteasome complex, the immunoproteasome, is the processing of numerous MHC class-I restricted T cell epitopes.^[9]

^ ^a ^b ^c ENSG00000243067, ENSG00000240065, ENSG00000240508, ENSG00000242711, ENSG00000243594, ENSG00000243958, ENSG00000239836 GRCh38: Ensembl release 89: ENSG00000240118, ENSG00000243067, ENSG00000240065, ENSG00000240508, ENSG00000242711, ENSG00000243594, ENSG00000243958, ENSG00000239836 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (Oct 1991). "Second proteasome-related gene in the human MHC class II region". Nature. 353 (6345): 667–8. Bibcode:1991Natur.353..667K. doi:10.1038/353667a0. PMID 1922385. S2CID 4344064.
^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Apr 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
^ "Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)".
^ Coux O, Tanaka K, Goldberg AL (Nov 1996). "Structure and functions of the 20S and 26S proteasomes". Annual Review of Biochemistry. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
^ Basler M, Kirk CJ, Groettrup M (Feb 2013). "The immunoproteasome in antigen processing and other immunological functions". Current Opinion in Immunology (Submitted manuscript). 25 (1): 74–80. doi:10.1016/j.coi.2012.11.004. PMID 23219269.

[refGRCh38Ensembl-1] ENSG00000243067, ENSG00000240065, ENSG00000240508, ENSG00000242711, ENSG00000243594, ENSG00000243958, ENSG00000239836 GRCh38: Ensembl release 89: ENSG00000240118, ENSG00000243067, ENSG00000240065, ENSG00000240508, ENSG00000242711, ENSG00000243594, ENSG00000243958, ENSG00000239836 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000096727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1922385-5] Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (Oct 1991). "Second proteasome-related gene in the human MHC class II region". Nature. 353 (6345): 667–8. Bibcode:1991Natur.353..667K. doi:10.1038/353667a0. PMID 1922385. S2CID 4344064.

[pmid1529427-6] Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Apr 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.

[entrez-7] "Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)".

[pmid8811196-8] Coux O, Tanaka K, Goldberg AL (Nov 1996). "Structure and functions of the 20S and 26S proteasomes". Annual Review of Biochemistry. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.

[9] Basler M, Kirk CJ, Groettrup M (Feb 2013). "The immunoproteasome in antigen processing and other immunological functions". Current Opinion in Immunology (Submitted manuscript). 25 (1): 74–80. doi:10.1016/j.coi.2012.11.004. PMID 23219269.

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