PTEN (gene)

PTEN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ
Identifiers
Aliases	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta
External IDs	OMIM: 601728; MGI: 109583; HomoloGene: 265; GeneCards: PTEN; OMA:PTEN - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 87,862,638 bp[1] End 87,971,930 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 28.14 cM Start 32,734,897 bp[2] End 32,803,560 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell Achilles tendon skin of arm pancreatic epithelial cell middle temporal gyrus parietal pleura mucosa of ileum cardiac muscle tissue of right atrium visceral pleura Top expressed in arcuate nucleus intercostal muscle median eminence olfactory tubercle granulocyte human fetus Rostral migratory stream ankle calvaria subcutaneous adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity phosphatidylinositol-3-phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity enzyme binding platelet-derived growth factor receptor binding protein binding protein kinase binding phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity anaphase-promoting complex binding identical protein binding hydrolase activity lipid binding ubiquitin-specific protease binding ionotropic glutamate receptor binding protein tyrosine kinase binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity PDZ domain binding Cellular component cytoplasm postsynaptic membrane extracellular region mitochondrion neuron projection cytoplasmic side of plasma membrane nucleus cell projection dendritic spine myelin sheath adaxonal region Schmidt-Lanterman incisure apical plasma membrane plasma membrane PML body nucleoplasm cytosol postsynaptic cytosol Biological process multicellular organismal response to stress regulation of neuron projection development response to zinc ion positive regulation of TRAIL-activated apoptotic signaling pathway response to organic substance negative regulation of G1/S transition of mitotic cell cycle regulation of B cell apoptotic process angiogenesis positive regulation of ERK1 and ERK2 cascade negative regulation of epithelial cell proliferation long-term depression positive regulation of excitatory postsynaptic potential cell population proliferation response to ethanol neuron projection development cellular response to hypoxia negative regulation of cell size negative regulation of cell population proliferation prepulse inhibition regulation of myeloid cell apoptotic process male mating behavior locomotory behavior dentate gyrus development positive regulation of apoptotic signaling pathway inositol phosphate metabolic process response to arsenic-containing substance memory forebrain morphogenesis dendritic spine morphogenesis heart development central nervous system development negative regulation of axonogenesis regulation of cellular localization synapse maturation learning or memory social behavior synapse assembly cellular response to decreased oxygen levels prostate gland growth platelet-derived growth factor receptor signaling pathway negative regulation of dendritic spine morphogenesis brain morphogenesis negative regulation of protein phosphorylation regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cellular component size response to nutrient negative regulation of synaptic vesicle clustering postsynaptic density assembly protein dephosphorylation protein stabilization positive regulation of DNA-binding transcription factor activity negative regulation of apoptotic process response to glucose nervous system development adult behavior phosphatidylinositol dephosphorylation positive regulation of ubiquitin-dependent protein catabolic process response to inorganic substance canonical Wnt signaling pathway phosphatidylinositol biosynthetic process negative regulation of organ growth negative regulation of ribosome biogenesis dephosphorylation locomotor rhythm central nervous system myelin maintenance regulation of axon regeneration response to estradiol response to ATP negative regulation of phagocytosis response to organic cyclic compound protein kinase B signaling cardiac muscle tissue development lipid metabolism ageing neuron-neuron synaptic transmission negative regulation of excitatory postsynaptic potential presynaptic membrane assembly regulation of cell cycle maternal behavior rhythmic synaptic transmission positive regulation of cell population proliferation positive regulation of apoptotic process negative regulation of ERK1 and ERK2 cascade cell migration negative regulation of myelination inositol phosphate dephosphorylation regulation of synaptic transmission, GABAergic endothelial cell migration central nervous system neuron axonogenesis long-term potentiation peptidyl-tyrosine dephosphorylation negative regulation of axon regeneration negative regulation of cardiac muscle cell proliferation positive regulation of ubiquitin protein ligase activity protein deubiquitination negative regulation of epithelial to mesenchymal transition negative regulation of keratinocyte migration cellular response to electrical stimulus negative regulation of wound healing, spreading of epidermal cells negative regulation of phosphatidylinositol 3-kinase signaling positive regulation of gene expression positive regulation of cardiac muscle cell apoptotic process response to activity cellular response to insulin stimulus cellular response to leptin stimulus positive regulation of neuron differentiation cellular response to ethanol negative regulation of potassium ion transmembrane transporter activity cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus negative regulation of signaling receptor activity negative regulation of protein kinase B signaling apoptotic process negative regulation of cell migration regulation of protein stability negative regulation of focal adhesion assembly negative regulation of vascular associated smooth muscle cell proliferation transcription initiation from RNA polymerase II promoter negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5728 19211 Ensembl ENSG00000171862 ENSG00000284792 ENSMUSG00000013663 UniProt P60484 O08586 RefSeq (mRNA) NM_000314 NM_001304717 NM_001304718 NM_008960 NM_177096 RefSeq (protein) NP_000305 NP_001291646 NP_001291647 NP_000305.3 NP_032986 Location (UCSC) Chr 10: 87.86 – 87.97 Mb Chr 19: 32.73 – 32.8 Mb PubMed search [3] [4]
Wikidata
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Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene.^[6] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs)^[7] have been identified in most mammals for which complete genome data are available.

PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly.^[8] It is a target of many anticancer drugs.

The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating the Akt/PKB signaling pathway.^[9]