PTGES3

PTGES3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EJF
Identifiers
Aliases	PTGES3, P23, TEBP, cPGES, prostaglandin E synthase 3
External IDs	OMIM: 607061; MGI: 1929282; HomoloGene: 128197; GeneCards: PTGES3; OMA:PTGES3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,688,408 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,913,141 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; gonad; ; mucosa of sigmoid colon; ; caput epididymis; ; ventricular zone; ; embryo; ; ganglionic eminence; ; corpus epididymis; ; trabecular bone;
	Top expressed in
	abdominal wall; ; medullary collecting duct; ; renal corpuscle; ; Gonadal ridge; ; endocardial cushion; ; cumulus cell; ; primitive streak; ; vas deferens; ; migratory enteric neural crest cell; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	unfolded protein binding; telomerase activity; isomerase activity; protein binding; prostaglandin-E synthase activity; Hsp90 protein binding; DNA polymerase binding; chaperone binding;
Cellular component	nucleoplasm; telomere; telomerase holoenzyme complex; extracellular exosome; nucleus; cytoplasm; cytosol; protein-containing complex; chaperone complex;
Biological process	prostaglandin metabolic process; lipid metabolism; cyclooxygenase pathway; fatty acid metabolic process; fatty acid biosynthetic process; regulation of cellular response to heat; prostaglandin biosynthetic process; telomere maintenance; signal transduction; xenobiotic metabolic process; telomere maintenance via telomerase; positive regulation of phosphorylation; positive regulation of telomerase activity; telomerase holoenzyme complex assembly; protein stabilization; chaperone-mediated protein complex assembly; protein folding; chaperone cofactor-dependent protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	10728
	56351
	ENSG00000110958
	ENSMUSG00000071072
	Q15185
	Q9R0Q7
NM_001282601; NM_001282602; NM_001282603; NM_001282604; NM_001282605;
	NM_006601
	NM_019766
NP_001269530; NP_001269531; NP_001269532; NP_001269533; NP_001269534;
	NP_006592
	NP_062740
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene.^[5]

The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning of the glucocorticoid and other steroid receptors.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110958 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071072 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PTGES3 Prostaglandin E synthase 3 (cytosolic)".
^ Freeman BC, Yamamoto KR (June 2002). "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science. 296 (5576): 2232–2235. Bibcode:2002Sci...296.2232F. doi:10.1126/science.1073051. PMID 12077419. S2CID 8844179.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110958 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071072 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: PTGES3 Prostaglandin E synthase 3 (cytosolic)".

[pmid12077419-6] Freeman BC, Yamamoto KR (June 2002). "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science. 296 (5576): 2232–2235. Bibcode:2002Sci...296.2232F. doi:10.1126/science.1073051. PMID 12077419. S2CID 8844179.

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