PTK2

PTK2
Available structures PDB Ortholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes 4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU6, 4GU9, 4I4E, 4I4F, 4K8A, 4K9Y, 4KAB, 4KAO, 4NY0
Identifiers
Aliases	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pFAK, CT28129, CG10023, Fak56D, DmFAK
External IDs	OMIM: 600758; MGI: 95481; HomoloGene: 7314; GeneCards: PTK2; OMA:PTK2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 56D5-56D5|2-89 cM Start 19,430,659 bp End 19,437,259 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse)[1] Band 15 D3|15 33.94 cM Start 73,205,102 bp[1] End 73,423,280 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ovary testicle testicle ovary ovary antenna gut ovary antenna gut Top expressed in left lung lobe Gonadal ridge dermis medullary collecting duct tail of embryo dentate gyrus of hippocampal formation granule cell mandibular prominence human fetus maxillary prominence prefrontal cortex More reference expression data BioGPS 37233/ More reference expression data
Gene ontology Molecular function SH2 domain binding kinase activity signaling receptor binding ATP binding protein kinase activity JUN kinase binding non-membrane spanning protein tyrosine kinase activity transferase activity protein binding protein kinase binding nucleotide binding actin binding protein tyrosine kinase activity protein phosphatase binding Cellular component cytoplasm cytosol membrane focal adhesion extrinsic component of cytoplasmic side of plasma membrane microtubule organizing center cytoskeleton nucleus stress fiber apical plasma membrane lamellipodium plasma membrane cell cortex cell junction dendritic spine adherens junction Biological process regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of cell adhesion mediated by integrin placenta development vasculogenesis protein phosphorylation vascular endothelial growth factor receptor signaling pathway growth hormone receptor signaling pathway blood vessel development regulation of osteoblast differentiation angiogenesis transforming growth factor beta receptor signaling pathway cellular response to transforming growth factor beta stimulus positive regulation of protein kinase B signaling Fc-gamma receptor signaling pathway involved in phagocytosis cell motility regulation of GTPase activity signal complex assembly regulation of epithelial cell migration negative regulation of axonogenesis regulation of endothelial cell migration establishment of cell polarity regulation of focal adhesion assembly phosphorylation netrin-activated signaling pathway negative regulation of synapse assembly extracellular matrix organization negative regulation of apoptotic process neuron migration positive regulation of ubiquitin-dependent protein catabolic process regulation of cell shape integrin-mediated signaling pathway regulation of substrate adhesion-dependent cell spreading negative regulation of organ growth microtubule cytoskeleton organization negative regulation of anoikis positive regulation of protein kinase activity negative regulation of cell-cell adhesion positive regulation of cell migration ephrin receptor signaling pathway heart morphogenesis MAPK cascade axon guidance positive regulation of phosphatidylinositol 3-kinase activity multicellular organism development regulation of cell population proliferation positive regulation of cell population proliferation positive regulation of phosphatidylinositol 3-kinase signaling regulation of cytoskeleton organization endothelial cell migration central nervous system neuron axonogenesis innate immune response peptidyl-tyrosine phosphorylation epidermal growth factor receptor signaling pathway protein autophosphorylation nuclear migration negative regulation of autophagy positive regulation of cardiac muscle hypertrophy peptidyl-tyrosine autophosphorylation cell differentiation regulation of cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5747,37233 5747,37233 14083 Ensembl ENSG00000169398 FBgn0020440 ENSMUSG00000022607 UniProt Q05397 P34152 RefSeq (mRNA) NM_001199649 NM_005607 NM_153831 NM_001316342 NM_001144246 NM_001144247 NM_001169736 NM_079069 NM_166352 NM_166353 NM_001130409 NM_007982 NM_001358045 NM_001358046 RefSeq (protein) NP_001186578 NP_001303271 NP_005598 NP_722560 NP_001339623 NP_001339624 NP_001339625 NP_001339626 NP_001339627 NP_001339628 NP_001339629 NP_001339630 NP_001339631 NP_001339632 NP_001339633 NP_001339634 NP_001339635 NP_001339636 NP_001339637 NP_001339638 NP_001339639 NP_001339640 NP_001339641 NP_001339642 NP_001339643 NP_001339644 NP_001339645 NP_001339646 NP_001339647 NP_001339648 NP_001339649 NP_001339650 NP_001339651 NP_001339652 NP_001339653 NP_001339654 NP_001339655 NP_001339656 NP_001339657 NP_001339658 NP_001339659 NP_001339660 NP_001339661 NP_001339662 NP_001339663 NP_001339664 NP_001339665 NP_001339666 NP_001339667 NP_001339668 NP_001339669 NP_001339670 NP_001339671 NP_001339672 NP_001339673 NP_001339674 NP_001339675 NP_001339676 NP_001339677 NP_001339678 NP_001339679 NP_001339680 NP_001339681 NP_032008 NP_001344974 NP_001344975 Location (UCSC) Chr 2: 19.43 – 19.44 Mb Chr 15: 73.21 – 73.42 Mb PubMed search [2] [3]
Wikidata
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PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.^[4] PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around).^[5] It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.^[6]