PTK6

PTK6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RJA, 2KGT
Identifiers
Aliases	PTK6, BRK, protein tyrosine kinase 6
External IDs	OMIM: 602004; MGI: 99683; HomoloGene: 68494; GeneCards: PTK6; OMA:PTK6 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,537,376 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,844,582 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; human penis; ; skin of abdomen; ; skin of leg; ; mucosa of pharynx; ; gums; ; amniotic fluid; ; gingival epithelium; ; oral cavity; ; jejunal mucosa;
	Top expressed in
	jejunum; ; esophagus; ; lip; ; intestinal villus; ; blastocyst; ; skin of external ear; ; tongue; ; ileum; ; Ileal epithelium; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; identical protein binding; signaling receptor binding; ATP binding; protein tyrosine kinase activity;
Cellular component	cytoplasm; cell projection; membrane; ruffle; extrinsic component of cytoplasmic side of plasma membrane; nucleus; nucleoplasm; cytosol; plasma membrane; nuclear body;
Biological process	cellular response to retinoic acid; negative regulation of growth; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; negative regulation of protein tyrosine kinase activity; regulation of cell population proliferation; intestinal epithelial cell differentiation; positive regulation of neuron projection development; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; innate immune response; cell migration; positive regulation of cell cycle; ERBB2 signaling pathway; negative regulation of signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; tyrosine phosphorylation of STAT protein; positive regulation of tyrosine phosphorylation of STAT protein; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5753
	20459
	ENSG00000101213
	ENSMUSG00000038751
	Q13882
	Q64434
	NM_001256358; NM_005975
	NM_009184; NM_001356304
	NP_001243287; NP_005966
	NP_033210; NP_001343233
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101213 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
^ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935.
^ "PTK6 protein tyrosine kinase 6". National Center for Biotechnology Information (NCBI). 4 June 2020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101213 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038751 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8247543-5] Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.

[pmid9284935-6] Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935.

[entrez-7] "PTK6 protein tyrosine kinase 6". National Center for Biotechnology Information (NCBI). 4 June 2020.

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