PTPN1

PTPN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A5Y, 1AAX, 1BZC, 1BZH, 1BZJ, 1C83, 1C84, 1C85, 1C86, 1C87, 1C88, 1ECV, 1EEN, 1EEO, 1G1F, 1G1G, 1G1H, 1G7F, 1G7G, 1GFY, 1I57, 1JF7, 1KAK, 1KAV, 1L8G, 1LQF, 1NL9, 1NNY, 1NO6, 1NWE, 1NWL, 1NZ7, 1OEM, 1OEO, 1OES, 1OET, 1OEV, 1ONY, 1ONZ, 1PA1, 1PH0, 1PTT, 1PTU, 1PTV, 1PTY, 1PXH, 1PYN, 1Q1M, 1Q6J, 1Q6M, 1Q6N, 1Q6P, 1Q6S, 1Q6T, 1QXK, 1SUG, 1T48, 1T49, 1T4J, 1WAX, 1XBO, 2AZR, 2B07, 2B4S, 2BGD, 2BGE, 2CM2, 2CM3, 2CM7, 2CM8, 2CMA, 2CMB, 2CMC, 2CNE, 2CNF, 2CNG, 2CNH, 2CNI, 2F6F, 2F6T, 2F6V, 2F6W, 2F6Y, 2F6Z, 2F70, 2F71, 2FJM, 2FJN, 2H4G, 2H4K, 2HB1, 2HNP, 2HNQ, 2NT7, 2NTA, 2QBP, 2QBQ, 2QBR, 2QBS, 2VEU, 2VEV, 2VEW, 2VEX, 2VEY, 2ZMM, 2ZN7, 3A5J, 3A5K, 3CWE, 3D9C, 3EAX, 3EB1, 3EU0, 3I7Z, 3I80, 3QKP, 3QKQ, 3SME, 3ZMP, 3ZMQ, 3ZV2, 4BJO, 4I8N, 4QAH, 4QAP, 4QBE, 4QBW, 4Y14, 4ZRT
Identifiers
Aliases	PTPN1, PTP1B, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase non-receptor type 1
External IDs	OMIM: 176885; MGI: 97805; HomoloGene: 2119; GeneCards: PTPN1; OMA:PTPN1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 50,510,321 bp[1] End 50,585,241 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 167,773,977 bp[2] End 167,821,305 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung right lung spleen appendix monocyte lymph node granulocyte tibial arteries ascending aorta left adrenal gland Top expressed in tibiofemoral joint corneal stroma Rostral migratory stream granulocyte mesenteric lymph nodes stroma of bone marrow spleen Ileal epithelium decidua lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoprotein phosphatase activity insulin receptor binding phosphatase activity ephrin receptor binding receptor tyrosine kinase binding zinc ion binding protein binding protein tyrosine phosphatase activity protein phosphatase 2A binding enzyme binding hydrolase activity protein kinase binding RNA binding cadherin binding Cellular component cytoplasm cytosol endoplasmic reticulum membrane membrane plasma membrane early endosome endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane sorting endosome cytoplasmic vesicle protein-containing complex Biological process regulation of endocytosis actin cytoskeleton reorganization insulin receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway growth hormone receptor signaling pathway via JAK-STAT peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity negative regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein tyrosine kinase activity protein dephosphorylation regulation of hepatocyte growth factor receptor signaling pathway response to endoplasmic reticulum stress endoplasmic reticulum unfolded protein response regulation of intracellular protein transport positive regulation of IRE1-mediated unfolded protein response negative regulation of insulin receptor signaling pathway IRE1-mediated unfolded protein response regulation of type I interferon-mediated signaling pathway regulation of signal transduction negative regulation of MAP kinase activity positive regulation of receptor catabolic process negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of PERK-mediated unfolded protein response regulation of insulin receptor signaling pathway platelet-derived growth factor receptor-beta signaling pathway dephosphorylation negative regulation of signal transduction Unfolded Protein Response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5770 19246 Ensembl ENSG00000196396 ENSMUSG00000027540 UniProt P18031 P35821 RefSeq (mRNA) NM_002827 NM_001278618 NM_011201 RefSeq (protein) NP_001265547 NP_002818 NP_035331 Location (UCSC) Chr 20: 50.51 – 50.59 Mb Chr 2: 167.77 – 167.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene.^[5] PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes.^[6] It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well.^[7][8][9]