PUVA therapy

PUVA therapy
MeSHD011701

PUVA (psoralen and UVA) is an ultraviolet light therapy treatment for skin diseases: vitiligo, eczema, psoriasis, graft-versus-host disease, mycosis fungoides, large plaque parapsoriasis, and cutaneous T-cell lymphoma, using the sensitizing effects of the drug psoralen.[1]: 686 [2][3] The psoralen is applied or taken orally to sensitize the skin, then the skin is exposed to UVA.

Photodynamic therapy is the general use of nontoxic light-sensitive compounds that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells. Still, PUVA therapy is often classified as a separate technique from photodynamic therapy.[4][5]

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  2. ^ Domínguez MA, Membrillo VG, Ramos GA (2004). "Large plaque parapsoriasis and PUVA-therapy. A case report". Archived from the original on 2012-07-12. Retrieved 2012-03-23.
  3. ^ MacMillan Cancer Support Group. "Cutaneous T-cell lymphoma (CTCL)".
  4. ^ Finlan, L. E.; Kernohan, N. M.; Thomson, G.; Beattie, P. E.; Hupp, T. R.; Ibbotson, S. H. (2005). "Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet a therapy on p53 phosphorylation in normal human skin in vivo". British Journal of Dermatology. 153 (5): 1001–10. doi:10.1111/j.1365-2133.2005.06922.x. PMID 16225614. S2CID 35302348.
  5. ^ Champva Policy Manual, Chapter: 2, Section: 30.11, Title: PDT (Photodynamic Therapy) and PUVA (Photochemotherapy) at U.S. Department of Veterans Affairs. Date: 12/23/2011