Paget's disease of the breast

For other diseases named after Paget, see Paget's disease (disambiguation).
Paget's disease of the breast
Other namesPaget disease of the breast, Paget's disease of the nipple, Mammary Paget's disease[1]
Paget's disease of the nipple
Pronunciation
SpecialtyOncology Edit this on Wikidata
Named afterJames Paget

Paget's disease of the breast (also known as mammary Paget's disease) is a rare skin change at the nipple nearly always associated with underlying breast cancer.[2] Paget's disease of the breast was first described by Sir James Paget in 1874.[3] The condition is an uncommon disease accounting for 1 to 4% of all breast cancers cases.[2] 92% to 100% of patients with Paget's disease of the breast have an underlying breast cancer.[4]

The condition in itself often appears innocuous, limited to a surface appearance and it is sometimes dismissed, although it is actually indicative of underlying breast cancer.[3][5]

  1. ^ Dalberg K, Hellborg H, Wärnberg F (September 2008). "Paget's disease of the nipple in a population based cohort". Breast Cancer Research and Treatment. 111 (2): 313–9. doi:10.1007/s10549-007-9783-5. PMID 17952590. S2CID 21650163.
  2. ^ a b "Paget Disease of the Breast - NCI". www.cancer.gov. 2012-05-21. Retrieved 2023-10-09.
  3. ^ a b Thin, George (1881). "On the Connection Between Disease of the Nipple and Areola and Tumours of the Breast". Trans Pathol Soc Lond. 32: 218.
  4. ^ Markarian, Sione (2022-05-14). "Mammary Paget's Disease: An Update". Cancers. 14 (10): 2422. doi:10.3390/cancers14102422. PMC 9139704. PMID 35626023.
  5. ^ Karakas, Cansu (2011). "Paget's disease of the breast". Journal of Carcinogenesis. 10: 31. doi:10.4103/1477-3163.90676. ISSN 1477-3163. PMC 3263015. PMID 22279416.