The Palast Barberini, more recently also known as the Palais Barberini, was a classicist-baroque town house built under the Prussian King Frederick II according to designs by Carl von Gontard between 1771 and 1772 at Humboldtstraße 5/6 in Potsdam. Its main façade faces the Alter Markt with the Potsdam City Palace and the St. Nicholas church.
The building was named after the Palazzo Barberini in Rome, which the king had chosen as a model. The Potsdam recreation of the Italian model formed the monumental south-eastern end of the Alter Markt and, together with the neighboring Noacksches Haus at Humboldtstraße 4, also designed by Gontard, was one of the last buildings to be built around the square under Frederick II. In the middle of the 19th century, the palace building was extended by two side wings at the rear facing the Havel according to designs by Ludwig Persius and Ludwig Ferdinand Hesse and used as a venue for Potsdam's cultural and club life.
The Palast Barberini was largely destroyed in an air raid on April 14, 1945 and the ruins were demolished during the Soviet Occupation Zone. The site was then used as a green space and parking lot for a long time. As part of the redevelopment of the center of Potsdam with the reconstruction of the city palace as a new state parliament building and other buildings in the neighborhood, the Palast Barberini was rebuilt from 2013 to the end of 2016 with an exterior largely based on the original for use as the art gallery Museum Barberini after donations from the entrepreneur Hasso Plattner.