Palazzo Isnello (also known as Palazzo Termine d'Isnello or Palazzo Sant'Antimo al Cassaro) is an historic palazzo situated between the ancient via del Cassaro and Piazza Borsa, in the Kalsa quarter of Palermo, Sicily.
On the piano nobile of the house, the vault of the ballroom is frescoed with an Apotheosis of Palermo, one of seven monumental representations of the Genius of Palermo, ancient numen of the city. There is also a fresco depicting an allegory of The Four Seasons, painted by Francesco Sozzi.