Palisaded encapsulated neuroma

Palisaded encapsulated neuroma
Other namesSolitary circumscribed neuroma
Micrograph of a palisaded encapsulated neuroma
SpecialtyDermatology
Diagnostic methodHistopathology
Differential diagnosisNeurofibroma, basal cell carcinoma, melanocytic nevus, epidermoid cyst, skin appendage
TreatmentSurgical excision

Palisaded encapsulated neuroma (PEN) is a rare, benign cutaneous condition characterized by small, firm, non-pigmented nodules or papules.[1][2] They typically occur as a solitary (single) lesion near the mucocutaneous junction of the skin of the face, although they can occur elsewhere on the body.[3]

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ Dubovy, Sander R.; Clark, Brian J. (2001-08-01). "Palisaded encapsulated neuroma (solitary circumscribed neuroma of skin) of the eyelid: report of two cases and review of the literature". British Journal of Ophthalmology. 85 (8): 949–951. doi:10.1136/bjo.85.8.949. ISSN 0007-1161. PMC 1724085. PMID 11466253.
  3. ^ Newman, Marissa D; Milgraum, Sandy (2008). "Palisaded Encapsulated Neuroma (PEN): An often misdiagnosed neural tumor". Dermatol. Online J. 14 (7): 12. PMID 18718196 – via eScholarship.