Pamidronic acid

Pamidronic acid

Clinical data
Trade names	Aredia, Pamimed, among others
Other names	Pamidronate disodium pentahydrate, pamidronate disodium
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601163
Pregnancy category	AU: B3
Routes of administration	Intravenous
ATC code	M05BA03 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	n/a
Protein binding	54%
Metabolism	Nil
Elimination half-life	28 ± 7 hours
Excretion	Renal
Identifiers
IUPAC name (3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
CAS Number	40391-99-9 Y
PubChem CID	4674
IUPHAR/BPS	7259
DrugBank	DB00282 Y
ChemSpider	4512 Y
UNII	OYY3447OMC
KEGG	D07281 Y
ChEMBL	ChEMBL834 Y
CompTox Dashboard (EPA)	DTXSID4023414
ECHA InfoCard	100.049.897
Chemical and physical data
Formula	C3H11NO7P2
Molar mass	235.069 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=P(O)(O)C(O)(CCN)P(=O)(O)O
InChI InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11) Y Key:WRUUGTRCQOWXEG-UHFFFAOYSA-N Y
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Pamidronic acid or pamidronate disodium or APD (marketed as Aredia among others), is a nitrogen-containing bisphosphonate used to prevent osteoporosis.

It was patented in 1971 and approved for medical use in 1987.^[1]