Pannexin

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Purinergic signalling
Simplified illustration of extracellular purinergic signalling
Concepts

Purinergic signalling

Membrane transporters

Nucleoside transporters

Pannexin
Identifiers
SymbolPannexin
InterProIPR039099
TCDB1.A.25
pannexin 1
Identifiers
SymbolPANX1
NCBI gene24145
HGNC8599
OMIM608420
RefSeqNM_015368
UniProtQ96RD7
Other data
LocusChr. 11 q14-q21
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StructuresSwiss-model
DomainsInterPro
pannexin 2
Identifiers
SymbolPANX2
NCBI gene56666
HGNC8600
OMIM608421
RefSeqNM_052839
UniProtQ96RD6
Other data
LocusChr. 22 q13
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StructuresSwiss-model
DomainsInterPro
pannexin 3
Identifiers
SymbolPANX3
NCBI gene116337
HGNC20573
OMIM608422
RefSeqNM_052959
UniProtQ96QZ0
Other data
LocusChr. 11 q24.2
Search for
StructuresSwiss-model
DomainsInterPro

Pannexins (from Greek 'παν' — all, and from Latin 'nexus' — connection) are a family of vertebrate proteins identified by their homology to the invertebrate innexins.[1] While innexins are responsible for forming gap junctions in invertebrates, the pannexins have been shown to predominantly exist as large transmembrane channels connecting the intracellular and extracellular space, allowing the passage of ions and small molecules between these compartments (such as ATP and sulforhodamine B).

Three pannexins have been described in Chordates: Panx1, Panx2 and Panx3.[2]

  1. ^ Panchin Y, Kelmanson I, Matz M, Lukyanov K, Usman N, Lukyanov S (June 2000). "A ubiquitous family of putative gap junction molecules". Current Biology. 10 (13): R473-4. Bibcode:2000CBio...10.R473P. doi:10.1016/S0960-9822(00)00576-5. PMID 10898987. S2CID 20001454.
  2. ^ Litvin O, Tiunova A, Connell-Alberts Y, Panchin Y, Baranova A (2006). "What is hidden in the pannexin treasure trove: the sneak peek and the guesswork". Journal of Cellular and Molecular Medicine. 10 (3): 613–34. doi:10.1111/j.1582-4934.2006.tb00424.x. PMC 3933146. PMID 16989724.