Pardis Sabeti

Pardis Sabeti
Sabeti in 2011
Born
Pardis Christine Sabeti

(1975-12-25) 25 December 1975 (age 48)
Tehran, Iran
EducationMassachusetts Institute of Technology (BS)
New College, Oxford (MSc, DPhil)
Harvard University (MD)
AwardsTIME 100
National Academy of Medicine
Scientific career
FieldsEvolutionary genetics
Genetic epidemiology
Computational biology
InstitutionsHarvard University
Broad Institute
Howard Hughes Medical Institute
ThesisThe Effects of Natural Selection and Recombination on Genetic Diversity in Humans: An Investigation of Plasmodium Falciparum Malaria in African Populations (2002)
Doctoral advisorRyk Ward
Anthony Boyce[1]
WebsiteOfficial website

Pardis Christine Sabeti (Persian: پردیس ثابتی; born December 25, 1975) is an American computational biologist, medical geneticist, and evolutionary geneticist.[2] She is a professor in the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University, professor of Immunology and Infectious Disease at the Harvard T.H. Chan School of Public Health, core institute member at the Broad Institute, and an investigator of the Howard Hughes Medical Institute.[3][4]

Sabeti and her lab have pioneered technologies for detecting, tracking, and countering deadly pathogens, including Ebola,[5][6] Zika,[7] Lassa,[8][9] and SARS-CoV-2.[10][11]  They have also created some of the most powerful algorithms and molecular tools to characterize the human genome and transformative methods for gene delivery of new biomedicines to specific tissues.[12][13][14]

Sabeti was named one of Time Magazine's Persons of the Year in 2014 (Ebola Fighters), and one of the Time 100 most influential people in 2015.[15][16] Her continued efforts including during the COVID-19 pandemic led her to receive a Time 100 Impact Award and to be inducted into the National Academy of Medicine.[17][18] She is the current host of the educational series Against All Odds: Inside Statistics sponsored by Annenberg Learner and a Crash Course on Outbreak Science[19][20] and is the lead singer and a writer for the rock band Thousand Days.[21][22][23]

  1. ^ Cite error: The named reference dphil was invoked but never defined (see the help page).
  2. ^ Pardis Sabeti publications from Europe PubMed Central
  3. ^ "FAS Center for Systems Biology, Harvard University". Archived from the original on 17 May 2008.
  4. ^ "Pardis Sabeti". @broadinstitute. 6 July 2015. Retrieved 11 August 2024.
  5. ^ Gire, Stephen K.; Goba, Augustine; Andersen, Kristian G.; Sealfon, Rachel S. G.; Park, Daniel J.; Kanneh, Lansana; Jalloh, Simbirie; Momoh, Mambu; Fullah, Mohamed; Dudas, Gytis; Wohl, Shirlee; Moses, Lina M.; Yozwiak, Nathan L.; Winnicki, Sarah; Matranga, Christian B. (12 September 2014). "Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak". Science. 345 (6202): 1369–1372. Bibcode:2014Sci...345.1369G. doi:10.1126/science.1259657. ISSN 0036-8075. PMC 4431643. PMID 25214632.
  6. ^ Park, Daniel J.; Dudas, Gytis; Wohl, Shirlee; Goba, Augustine; Whitmer, Shannon L.M.; Andersen, Kristian G.; Sealfon, Rachel S.; Ladner, Jason T.; Kugelman, Jeffrey R.; Matranga, Christian B.; Winnicki, Sarah M.; Qu, James; Gire, Stephen K.; Gladden-Young, Adrianne; Jalloh, Simbirie (June 2015). "Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone". Cell. 161 (7): 1516–1526. doi:10.1016/j.cell.2015.06.007. PMC 4503805. PMID 26091036.
  7. ^ Metsky, Hayden C.; Matranga, Christian B.; Wohl, Shirlee; Schaffner, Stephen F.; Freije, Catherine A.; Winnicki, Sarah M.; West, Kendra; Qu, James; Baniecki, Mary Lynn; Gladden-Young, Adrianne; Lin, Aaron E.; Tomkins-Tinch, Christopher H.; Ye, Simon H.; Park, Daniel J.; Luo, Cynthia Y. (15 June 2017). "Zika virus evolution and spread in the Americas". Nature. 546 (7658): 411–415. Bibcode:2017Natur.546..411M. doi:10.1038/nature22402. ISSN 0028-0836. PMC 5563848. PMID 28538734.
  8. ^ Andersen, Kristian G.; Shapiro, B. Jesse; Matranga, Christian B.; Sealfon, Rachel; Lin, Aaron E.; Moses, Lina M.; Folarin, Onikepe A.; Goba, Augustine; Odia, Ikponwonsa; Ehiane, Philomena E.; Momoh, Mambu; England, Eleina M.; Winnicki, Sarah; Branco, Luis M.; Gire, Stephen K. (August 2015). "Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus". Cell. 162 (4): 738–750. doi:10.1016/j.cell.2015.07.020. PMC 4537774. PMID 26276630.
  9. ^ Siddle, Katherine J.; Eromon, Philomena; Barnes, Kayla G.; Mehta, Samar; Oguzie, Judith U.; Odia, Ikponmwosa; Schaffner, Stephen F.; Winnicki, Sarah M.; Shah, Rickey R.; Qu, James; Wohl, Shirlee; Brehio, Patrick; Iruolagbe, Christopher; Aiyepada, John; Uyigue, Eghosa (November 2018). "Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018". New England Journal of Medicine. 379 (18): 1745–1753. doi:10.1056/NEJMoa1804498. ISSN 0028-4793. PMC 6181183. PMID 30332564.
  10. ^ Lemieux, Jacob E.; Siddle, Katherine J.; Shaw, Bennett M.; Loreth, Christine; Schaffner, Stephen F.; Gladden-Young, Adrianne; Adams, Gordon; Fink, Timelia; Tomkins-Tinch, Christopher H.; Krasilnikova, Lydia A.; DeRuff, Katherine C.; Rudy, Melissa; Bauer, Matthew R.; Lagerborg, Kim A.; Normandin, Erica (5 February 2021). "Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events". Science. 371 (6529). doi:10.1126/science.abe3261. ISSN 0036-8075. PMC 7857412. PMID 33303686.
  11. ^ Siddle, Katherine J.; Krasilnikova, Lydia A.; Moreno, Gage K.; Schaffner, Stephen F.; Vostok, Johanna; Fitzgerald, Nicholas A.; Lemieux, Jacob E.; Barkas, Nikolaos; Loreth, Christine; Specht, Ivan; Tomkins-Tinch, Christopher H.; Paull, Jillian S.; Schaeffer, Beau; Taylor, Bradford P.; Loftness, Bryn (February 2022). "Transmission from vaccinated individuals in a large SARS-CoV-2 Delta variant outbreak". Cell. 185 (3): 485–492.e10. doi:10.1016/j.cell.2021.12.027. PMC 8695126. PMID 35051367.
  12. ^ Sabeti, Pardis C.; Reich, David E.; Higgins, John M.; Levine, Haninah Z. P.; Richter, Daniel J.; Schaffner, Stephen F.; Gabriel, Stacey B.; Platko, Jill V.; Patterson, Nick J.; McDonald, Gavin J.; Ackerman, Hans C.; Campbell, Sarah J.; Altshuler, David; Cooper, Richard; Kwiatkowski, Dominic (October 2002). "Detecting recent positive selection in the human genome from haplotype structure". Nature. 419 (6909): 832–837. Bibcode:2002Natur.419..832S. doi:10.1038/nature01140. ISSN 0028-0836. PMID 12397357.
  13. ^ The International HapMap Consortium; Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S. (October 2007). "Genome-wide detection and characterization of positive selection in human populations". Nature. 449 (7164): 913–918. Bibcode:2007Natur.449..913S. doi:10.1038/nature06250. ISSN 0028-0836. PMC 2687721. PMID 17943131.
  14. ^ Tewhey, Ryan; Kotliar, Dylan; Park, Daniel S.; Liu, Brandon; Winnicki, Sarah; Reilly, Steven K.; Andersen, Kristian G.; Mikkelsen, Tarjei S.; Lander, Eric S.; Schaffner, Stephen F.; Sabeti, Pardis C. (June 2016). "Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay". Cell. 165 (6): 1519–1529. doi:10.1016/j.cell.2016.04.027. PMC 4957403. PMID 27259153.
  15. ^ "Pardis Sabeti". Time Magazine. Retrieved 30 October 2020.
  16. ^ "Person of the Year 2014: Read the Ebola Scientists' Stories". Time Magazine. 10 December 2014. Retrieved 30 October 2020.
  17. ^ "Dr. Pardis Sabeti Is Changing How We Track Virus Outbreaks in Real Time". Time. 26 September 2022. Retrieved 2 February 2024.
  18. ^ "Dr. Pardis Sabeti is elected to the National Academy of Medicine". africa.harvard.edu. Retrieved 2 February 2024.
  19. ^ "Against All Odds, Inside Statistics". Annenberg Learner. Annenberg Foundation. Archived from the original on 30 November 2015. Retrieved 18 November 2018.
  20. ^ What Is Outbreak Science? Crash Course Outbreak Science #1, 7 September 2021, retrieved 2 February 2024
  21. ^ Furman, Eric (16 July 2007). "Geniuses who will change your life". CNN.com. Retrieved 27 July 2007.
  22. ^ Kahn, Joseph (14 June 2008). "Infectious melodies". Boston.com. Retrieved 14 June 2012.
  23. ^ "bio". thousand days. 14 June 2008. Archived from the original on 28 March 2013. Retrieved 12 October 2013.